Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Prospective study on physical activity and Alzheimer's disease-related biomarkers.
СтатьяTwin StudyНазвание и аннотация: Перевод в очереди
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Iso-Markku Paula, Tu Xin M, Rissman Robert A, Gillespie Nathan A, Elman Jeremy A, Fennema-Notestine Christine, Panizzon Matthew S, Reynolds Chandra A, Lyons Michael J, Kremen William S, Franz Carol E, Vietnam Era Twin Study of Aging
Аннотация
INTRODUCTION: Evidence regarding the association between physical activity (PA) and Alzheimer's disease (AD)-related biomarkers is scarce and inconsistent.
METHODS: At ages 56 and 67, 564 men from the Vietnam Era Twin Study of Aging reported their PA during the preceding week from which metabolic equivalent of energy expenditure (MET) hours were determined. At age 67 we assayed plasma AD-related biomarkers (phosphorylated tau [p-tau]217, neurofilament light chain [NfL], amyloid beta (Aβ)42/40 ratio, and glial fibrillary acidic protein [GFAP]). We used generalized estimating equations to test whether PA at ages 56 or 67 was associated with these biomarkers at 67.
RESULTS: Age 56 MET hours were inversely associated with NfL and GFAP at 67 (NfL: B = -0.10, 95% confidence interval [CI]: -0.17 to -0.03, GFAP: B = -0.08, 95% CI: -0.15 to -0.01) but were not significantly associated with p-tau217 or Aβ42/40 ratio.
DISCUSSION: Our NfL and GFAP results suggest that midlife PA may reduce risk for neurodegeneration in older age via amyloid-independent mechanisms.
METHODS: At ages 56 and 67, 564 men from the Vietnam Era Twin Study of Aging reported their PA during the preceding week from which metabolic equivalent of energy expenditure (MET) hours were determined. At age 67 we assayed plasma AD-related biomarkers (phosphorylated tau [p-tau]217, neurofilament light chain [NfL], amyloid beta (Aβ)42/40 ratio, and glial fibrillary acidic protein [GFAP]). We used generalized estimating equations to test whether PA at ages 56 or 67 was associated with these biomarkers at 67.
RESULTS: Age 56 MET hours were inversely associated with NfL and GFAP at 67 (NfL: B = -0.10, 95% confidence interval [CI]: -0.17 to -0.03, GFAP: B = -0.08, 95% CI: -0.15 to -0.01) but were not significantly associated with p-tau217 or Aβ42/40 ratio.
DISCUSSION: Our NfL and GFAP results suggest that midlife PA may reduce risk for neurodegeneration in older age via amyloid-independent mechanisms.