Frontiers in pharmacology · 2026
Mechanism of Icariin induces mitochondrial-mediated apoptosis by Wnt/β-catenin signaling pathway in colorectal cancer.
СтатьяНазвание и аннотация: Перевод в очереди
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Wang Xin, Lu Rui-Yun, Wang Hao-Bo, Li Yi-Jiong, Guo Li-Fang, Lan Tian-Hao, Pang Chao, Wang Cong-Hui, Zhang Jing, Shang Fang-Jian, Meng Li-Min, Zhao Zeng-Ren
Аннотация
BACKGROUND: To evaluate the effect of Icariin (ICA) on AOM/DSS-induced colorectal cancer (CRC) in mice as well as CRC cells, and to explore the underlying molecular mechanism.
METHODS: The therapeutic efficacy of ICA against AOM/DSS-induced CRC was evaluated by detecting tumor growth and pathological alterations. Biomarkers related to Wnt/β-catenin and mitochondrial apoptosis were tested, and cell experiments were performed to validate the regulatory correlation between ICA and the Wnt/β-catenin pathway in CRC cells.
RESULTS: ICA significantly reduced tumor number, size and ameliorated pathological damage in AOM/DSS-induced mice by regulating the mitochondrial-mediated apoptosis of colon tissue. ICA's regulation of mitochondrial-mediated apoptosis was confirmed to involve the Wnt/β-catenin signaling pathway. In vitro, ICA restrained proliferation, migration and invasion of SW1463 and HCT116 cells, decreased mitochondrial membrane potential and changed the expression of pathway-related genes.
CONCLUSION: The study demonstrated that ICA promoted mitochondrial-mediated apoptosis by regulating the Wnt/β-catenin signaling pathway, suggesting that ICA could serve as a potential treatment for CRC.
METHODS: The therapeutic efficacy of ICA against AOM/DSS-induced CRC was evaluated by detecting tumor growth and pathological alterations. Biomarkers related to Wnt/β-catenin and mitochondrial apoptosis were tested, and cell experiments were performed to validate the regulatory correlation between ICA and the Wnt/β-catenin pathway in CRC cells.
RESULTS: ICA significantly reduced tumor number, size and ameliorated pathological damage in AOM/DSS-induced mice by regulating the mitochondrial-mediated apoptosis of colon tissue. ICA's regulation of mitochondrial-mediated apoptosis was confirmed to involve the Wnt/β-catenin signaling pathway. In vitro, ICA restrained proliferation, migration and invasion of SW1463 and HCT116 cells, decreased mitochondrial membrane potential and changed the expression of pathway-related genes.
CONCLUSION: The study demonstrated that ICA promoted mitochondrial-mediated apoptosis by regulating the Wnt/β-catenin signaling pathway, suggesting that ICA could serve as a potential treatment for CRC.