Journal of asthma and allergy · 2025
Bronchodilator Response Assessed by Surface Respiratory Muscle EMG in Children.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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He Baiting, Li Feng, Liu Simin, Wang Lu, Chen Zhiqiang, Zhu Qihua, Wang Lishuang, Liang Shanfeng, Al-Sherif Miral, Sun Lihong, Luo Yuanming
Аннотация
BACKGROUND: An increase of ≥ 12% in forced expiratory volume in the first second (FEV1) after inhalation of bronchodilator indicates airway reversibility. However, it is difficult to measure FEV1 in children. The aim of the study is to determine whether respiratory muscle electromyograms recorded from chest wall surface electrodes can be used to distinguish children with uncontrolled asthma from healthy subjects.
METHODS: Fourteen children with uncontrolled asthma [aged 6.1 (3 ~ 13) years] and 28 healthy children [aged 7.6 (3 ~ 13) years] were recruited. Uncontrolled asthma was defined as having poorly controlled symptoms, along with an increase in FEV1 of at least 12%, or presenting with a wheezing symptom that improved after inhaling a bronchodilator. Diaphragm electromyogram (EMGdi), parasternal intercostal EMG (EMGpara), airflow, FEV1, and wheezing were recorded before and after inhalation of bronchodilator.
RESULTS: Good-quality EMGdi and EMGpara could be recorded in all subjects. However, 18 of 42 children could not perform the spirometer properly. Changes in EMGdi [-24.6% (-43.5 ~ -12.4%) vs -0.1% (-13.2 ~ 16.9%), p<0.001] and EMGpara [-11.2% (-31.5 ~ 32.4%) vs -0.5% (-24.9 ~ 13.0%), p<0.05] in children with asthma were, respectively, significantly larger than those in healthy subjects during bronchodilator response. The area under the receiver operating characteristic curves for the changes of EMGdi and EMGpara were 0.995 (95% CI 0.906 to 1.000) and 0.755 (95% CI 0.598 to 0.874).
CONCLUSION: Surface respiratory muscle EMG could be feasible and useful to assess bronchodilator response to differentiate children with uncontrolled asthma from healthy subjects.
METHODS: Fourteen children with uncontrolled asthma [aged 6.1 (3 ~ 13) years] and 28 healthy children [aged 7.6 (3 ~ 13) years] were recruited. Uncontrolled asthma was defined as having poorly controlled symptoms, along with an increase in FEV1 of at least 12%, or presenting with a wheezing symptom that improved after inhaling a bronchodilator. Diaphragm electromyogram (EMGdi), parasternal intercostal EMG (EMGpara), airflow, FEV1, and wheezing were recorded before and after inhalation of bronchodilator.
RESULTS: Good-quality EMGdi and EMGpara could be recorded in all subjects. However, 18 of 42 children could not perform the spirometer properly. Changes in EMGdi [-24.6% (-43.5 ~ -12.4%) vs -0.1% (-13.2 ~ 16.9%), p<0.001] and EMGpara [-11.2% (-31.5 ~ 32.4%) vs -0.5% (-24.9 ~ 13.0%), p<0.05] in children with asthma were, respectively, significantly larger than those in healthy subjects during bronchodilator response. The area under the receiver operating characteristic curves for the changes of EMGdi and EMGpara were 0.995 (95% CI 0.906 to 1.000) and 0.755 (95% CI 0.598 to 0.874).
CONCLUSION: Surface respiratory muscle EMG could be feasible and useful to assess bronchodilator response to differentiate children with uncontrolled asthma from healthy subjects.