The Laryngoscope · 2025
Chronic Sinusitis With Nasal Polyps and Olfactory Dysfunction: Comparing Olfactory Training and Glucocorticoid Treatment.
СтатьяРандомизированное исследованиеСравнительное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhang Zhiqiang, Tu Junhao, Tang Binxiang, Xiong Yishan, Jia Yizhen, Zhang Meiping, Peng Hao, Jiang Fan, Chen Ningwu, Luo Qing, Ye Jing
Аннотация
OBJECTIVE: Few studies have compared the effectiveness of olfactory training (OT) and glucocorticoids (GC) in the phenotype of chronic sinusitis with nasal polyps (CRSwNP) with olfactory dysfunction (OD). To evaluate the effects of GC and OT on OD in patients with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) and non-eosinophilic chronic rhinosinusitis with nasal polyps (NonECRSwNP).
METHODS: After 2 weeks of endoscopic sinus surgery, patients with a composite threshold discrimination identification score (TDIS) of less than 30.5 were randomly assigned to receive GC (n = 38), OT (n = 36), or both (n = 34). Retrospective phenotypic stratification of CRSwNP patients was performed based on whether eosinophils in the tissue exceeded 10% (ECRSwNP and NonECRSwNP). Follow-up assessments were conducted at 1, 3, and 6 months postintervention. Evaluations included TDIS, the 22-item Sino-Nasal outcome test (SNOT-22), Lund-Kennedy endoscopic scores (LKES), and the frequency of olfactory fluctuations (OF).
RESULTS: SNOT-22 and LKES improved significantly over time. At 1 month, TDIS change was higher in the GCwOT group than in the GC or OT groups. By 6 months, GCwOT remained superior to GC but not to OT. Follow-up showed no difference between GC and OT. In ECRSwNP patients, GCwOT showed greater TDIS changes at 3 and 6 months versus GC, with lower OF incidence (p < 0.0125). In NonECRSwNP, GCwOT outperformed OT only at 1 month.
CONCLUSION: GC combined with OT can reduce OF in patients with ECRSwNP and consistently enhance olfactory function.
TRIAL REGISTRATION: ChiCTR2100049551.
METHODS: After 2 weeks of endoscopic sinus surgery, patients with a composite threshold discrimination identification score (TDIS) of less than 30.5 were randomly assigned to receive GC (n = 38), OT (n = 36), or both (n = 34). Retrospective phenotypic stratification of CRSwNP patients was performed based on whether eosinophils in the tissue exceeded 10% (ECRSwNP and NonECRSwNP). Follow-up assessments were conducted at 1, 3, and 6 months postintervention. Evaluations included TDIS, the 22-item Sino-Nasal outcome test (SNOT-22), Lund-Kennedy endoscopic scores (LKES), and the frequency of olfactory fluctuations (OF).
RESULTS: SNOT-22 and LKES improved significantly over time. At 1 month, TDIS change was higher in the GCwOT group than in the GC or OT groups. By 6 months, GCwOT remained superior to GC but not to OT. Follow-up showed no difference between GC and OT. In ECRSwNP patients, GCwOT showed greater TDIS changes at 3 and 6 months versus GC, with lower OF incidence (p < 0.0125). In NonECRSwNP, GCwOT outperformed OT only at 1 month.
CONCLUSION: GC combined with OT can reduce OF in patients with ECRSwNP and consistently enhance olfactory function.
TRIAL REGISTRATION: ChiCTR2100049551.