m+Medelevator.RU
← Поиск публикаций
medRxiv : the preprint server for health sciences · 2025

Genome-wide association studies of binge eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.

СтатьяПрепринтНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Termorshuizen Jet D, Davies Helena L, Lee Sang-Hyuck, Dennis Jessica K, Hübel Christopher, Johnson Jessica S, Lu Yi, Munn-Chernoff Melissa A, Peters Triinu, Qi Baiyu, Schaumberg Katherine E, Signer Rebecca H, Singh Karanvir, Ter Kuile Abigail R, Thornton Laura M, Xu Jiayi, Yao Shuyang, Yilmaz Zeynep, Zhang Ruyue, Zvrskovec Johan, Abdulkadir Mohamed, Ayorech Ziada, Corfield Elizabeth C, Havdahl Alexandra, Krebs Kristi, Mack Taralynn M, Niarchou Maria, Palviainen Teemu, Sealock Julia M, Baker Jessica H, Bergen Andrew W, Birgegård Andreas, Perica Vesna Boraska, Bühren Katharina, Burghardt Roland, Cassina Matteo, Collantoni Enrico, Crowley James J, Danner Unna N, Degenhardt Franziska, DeSocio Janiece E, Dina Christian, Dmitrzak-Węglarz Monika, Duncan Laramie E, Egberts Karin M, Foretova Lenka, Giegling Ina, Gonidakis Fragiskos, Gordon Scott D, Grove Jakob, Guillaume Sébastien, Guintivano Jerry D, Hartman Annette M, Hatzikotoulas Konstantinos, Herms Stefan, Imgart Hartmut, Jiménez-Murcia Susana, Julià Antonio, Kalsi Gursharan, Kaminská Deborah, Karhunen Leila J, Kiezebrink Kirsty M, Kolb Theresa, Larsen Janne T, Li Dong, Lilenfeld Lisa, Maj Mario, Mattingsdal Morten, Meneguzzo Paolo, Miller Allison L, Mitchell Karen S, Monteleone Alessio Maria, Olsen Catherine M, Padyukov Leonid, Pantel Jacques, Parker Richard, Pinto Dalila, Raevuori Anu, Ripatti Samuli, Roberts Marion E, Santonastaso Paolo, Savva Androula, Schmidt Ulrike H, Schosser Alexandra, Seitz Jochen, Slachtova Lenka Ls, Slopien Agnieszka, Sorbi Sandro, Straub Peter S, Szatkiewicz Jin P, Tam Friederike I, Tenconi Elena, Tortorella Alfonso, Tsitsika Artemis, van Elburg Annemarie A, Wagner Gudrun, Watson Hunna J, Adan Roger Ah, Alfredsson Lars, Andreassen Ole A, Ask Helga, Brandt Harry A, Crawford Steven, Crow Scott, Davis Lea K, de Zwaan Martina, Dedoussis George, Dick Danielle M, Ehrlich Stefan, Estivill Xavier, Favaro Angela, Fernández-Aranda Fernando, Fischer Krista, Forstner Andreas J, Gorwood Philip, Hakonarson Hakon, Hebebrand Johannes, Herpertz-Dahlmann Beate, Hinney Anke, Hudson James I, Johnson Craig, Jordan Jennifer, Kaplan Allan S, Kaprio Jaakko, Karwautz Andreas Fk, Kas Martien Jh, Kaye Walter H, Kennedy James L, Kennedy Martin A, Keski-Rahkonen Anna, Kim Youl-Ri, Klump Kelly L, Landén Mikael, Hellard Stéphanie Le, Lehto Kelli, Lissowska Jolanta, Maguire Sarah L, Martin Nicholas G, Mattheisen Manuel, Medland Sarah E, Micali Nadia, Mitchell James E, Monteleone Palmiero, Mortensen Preben Bo, Nacmias Benedetta, Ophoff Roel A, Papezova Hana, Pedersen Nancy L, Petersen Liselotte V, Rajcsanyi Louisa S, Ramoz Nicolas, Reichborn-Kjennerud Ted, Ricca Valdo, Ripke Stephan, Rujescu Dan, Rybakowski Filip, Scherer Stephen W, Slof-Op 't Landt Margarita Ct, Sullivan Patrick F, Świątkowska Beata, van Furth Eric F, Wade Tracey D, Werge Thomas, Whiteman David C, Woodside D Blake, Zipfel Stephan, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Estonian Biobank (EstBB), Bulik Cynthia M, Huckins Laura M, Breen Gerome, Coleman Jonathan Ri

Аннотация

Eating disorders -including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder-are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. We conducted the first genomic meta-analysis of binge eating behaviour (BE; 39,279 cases, 1,227,436 controls), alongside new analyses of AN (24,223 cases, 1,243,971 controls) and its subtypes (all European ancestries). We identified six loci associated with BE, including loci associated with higher body mass index (BMI) and impulse-control behaviours. AN GWAS yielded eight loci, validating six loci. Subsequent polygenic risk score analysis demonstrated an association with AN in two East Asian ancestry cohorts. BE and AN exhibited similar positive genetic correlations with psychiatric disorders, but opposing genetic correlations with anthropometric traits. Most of the genetic signal in BE and AN was not shared with BMI. We have extended eating disorder genomics beyond AN; future work will incorporate multiple diagnoses and global ancestries.

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты