Acta oto-laryngologica · 2025
The correlation between periostin and eosinophillic cationic protein demonstrate its potential biomarker of mucosal remodeling in chronic rhinosinusitis with nasal polyps.
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Maharani Iriana, Fitri Loeki Enggar, Djajalaksana Susanthy, Handoko Edi, Adi Pradana Yudha
Аннотация
INTRODUCTION: Chronic rhinosinusitis (CRS) is classified into CRS with nasal polyps (CRSwNP), a type 2 inflammation with elevated CLC and ECP levels, and CRS without nasal polyps (CRSsNP), a non-type 2 inflammation. Periostin plays a crucial role in mucosal remodeling, but its involvement in CRSwNP remains unclear.
AIMS/OBJECTIVES: To investigate correlation between CRSwNP endotype and periostin levels.
MATERIALS AND METHODS: This cross-sectional study measured endotype biomarkers (ECP, CLC, IFN-γ, IL-17A) and periostin levels in uncinate process and nasal polyps using ELISA to assess their correlation.
RESULTS: 99.6% of uncinate process and 36.67% of nasal polyp tissue samples displayed a mixed endotype pattern, while 2 samples were untype-able. Periostin levels were significantly higher in nasal polyp compared to uncinate process tissue (p = .0116) and control. Only ECP levels in the uncinate process showed a significant correlation with periostin (r = 0.326, p = .038).
CONCLUSION AND SIGNIFICANCE: Periostin is significantly elevated in nasal polyps, highlighting its role in CRSwNP. Its correlation with ECP in the uncinate process suggests involvement in inflammation, warranting further research into periostin as a therapeutic target. This study confirms periostin's role in CRSwNP, it potentially occurs with or without depending on the CRS endotype pathways.
AIMS/OBJECTIVES: To investigate correlation between CRSwNP endotype and periostin levels.
MATERIALS AND METHODS: This cross-sectional study measured endotype biomarkers (ECP, CLC, IFN-γ, IL-17A) and periostin levels in uncinate process and nasal polyps using ELISA to assess their correlation.
RESULTS: 99.6% of uncinate process and 36.67% of nasal polyp tissue samples displayed a mixed endotype pattern, while 2 samples were untype-able. Periostin levels were significantly higher in nasal polyp compared to uncinate process tissue (p = .0116) and control. Only ECP levels in the uncinate process showed a significant correlation with periostin (r = 0.326, p = .038).
CONCLUSION AND SIGNIFICANCE: Periostin is significantly elevated in nasal polyps, highlighting its role in CRSwNP. Its correlation with ECP in the uncinate process suggests involvement in inflammation, warranting further research into periostin as a therapeutic target. This study confirms periostin's role in CRSwNP, it potentially occurs with or without depending on the CRS endotype pathways.