Nature genetics · 2024

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.

СтатьяПоддержка NIH: внешняя программаПоддержка правительства СШАПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди

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Meng Xiangrui, Navoly Georgina, Giannakopoulou Olga, Levey Daniel F, Koller Dora, Pathak Gita A, Koen Nastassja, Lin Kuang, Adams Mark J, Rentería Miguel E, Feng Yanzhe, Gaziano J Michael, Stein Dan J, Zar Heather J, Campbell Megan L, van Heel David A, Trivedi Bhavi, Finer Sarah, McQuillin Andrew, Bass Nick, Chundru V Kartik, Martin Hilary C, Huang Qin Qin, Valkovskaya Maria, Chu Chia-Yi, Kanjira Susan, Kuo Po-Hsiu, Chen Hsi-Chung, Tsai Shih-Jen, Liu Yu-Li, Kendler Kenneth S, Peterson Roseann E, Cai Na, Fang Yu, Sen Srijan, Scott Laura J, Burmeister Margit, Loos Ruth J F, Preuss Michael H, Actkins Ky'Era V, Davis Lea K, Uddin Monica, Wani Agaz H, Wildman Derek E, Aiello Allison E, Ursano Robert J, Kessler Ronald C, Kanai Masahiro, Okada Yukinori, Sakaue Saori, Rabinowitz Jill A, Maher Brion S, Uhl George, Eaton William, Cruz-Fuentes Carlos S, Martinez-Levy Gabriela A, Campos Adrian I, Millwood Iona Y, Chen Zhengming, Li Liming, Wassertheil-Smoller Sylvia, Jiang Yunxuan, Tian Chao, Martin Nicholas G, Mitchell Brittany L, Byrne Enda M, Awasthi Swapnil, Coleman Jonathan R I, Ripke Stephan, PGC-MDD Working Group, China Kadoorie Biobank Collaborative Group, 23andMe Research Team, Genes and Health Research Team, BioBank Japan Project, Sofer Tamar, Walters Robin G, McIntosh Andrew M, Polimanti Renato, Dunn Erin C, Stein Murray B, Gelernter Joel, Lewis Cathryn M, Kuchenbaecker Karoline

Аннотация

Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%). The multi-ancestry GWAS identified 53 significantly associated novel loci. For loci from GWAS in European ancestry samples, fewer than expected were transferable to other ancestry groups. Fine mapping benefited from additional sample diversity. A transcriptome-wide association study identified 205 significantly associated novel genes. These findings suggest that, for MD, increasing ancestral and global diversity in genetic studies may be particularly important to ensure discovery of core genes and inform about transferability of findings.

Предметные рубрики MeSH

Humans Genome-Wide Association Study Genetic Predisposition to Disease Major Depressive Disorder Depression Chromosome Mapping Polymorphism, Single Nucleotide

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.

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Аннотация

Предметные рубрики MeSH