Generalized pseudoxanthoma elasticum with deficiency of vitamin K-dependent clotting factors.

A patient with generalized cutis laxa-like pseudoxanthoma elasticum was found to have a congenital deficiency of vitamin K-dependent coagulation factors II, VII, IX, and X. This association may not be fortutious and may define a particular subset of pseudoxanthoma elasticum with an autosomal recessive inheritance and the clinical features of generalized cutis laxa.