Future cardiology · 2026
Association between the NAPLES score and malignant ventricular arrhythmias in cardiomyopathy patients.
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Okumuş Kübra, Çakmak Karaaslan Özge
Аннотация
BACKGROUND: Malignant ventricular arrhythmias are a major cause of sudden cardiac death in patients with cardiomyopathy. Traditional risk markers, including left ventricular ejection fraction, have limited ability to identify high-risk individuals.
OBJECTIVE: To investigate the association between the Naples Prognostic Score (NAPLES), a marker of inflammatory and nutritional status, and malignant ventricular arrhythmias in patients with cardiomyopathy and cardiac implantable electronic devices (CIEDs).
METHODS: This retrospective study included 299 patients with cardiomyopathy and CIEDs. The NAPLES score was calculated using serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio. Patients were classified into low (0-1) and high (2-4) NAPLES groups. Independent predictors were evaluated using multivariable logistic regression analysis.
RESULTS: Malignant ventricular arrhythmias were more common in patients with high NAPLES scores than in those with low scores (46.3% vs. 36.1%, p = 0.042). High NAPLES score was independently associated with malignant ventricular arrhythmias (OR: 2.00, 95% CI: 1.14-3.23, p = 0.027). Each one-point increase in NAPLES score was also associated with increased arrhythmic risk (OR: 1.40, 95% CI: 1.08-1.81, p = 0.018).
CONCLUSION: The NAPLES score is independently associated with malignant ventricular arrhythmias and may aid arrhythmic risk stratification in patients with cardiomyopathy and CIEDs.
OBJECTIVE: To investigate the association between the Naples Prognostic Score (NAPLES), a marker of inflammatory and nutritional status, and malignant ventricular arrhythmias in patients with cardiomyopathy and cardiac implantable electronic devices (CIEDs).
METHODS: This retrospective study included 299 patients with cardiomyopathy and CIEDs. The NAPLES score was calculated using serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio. Patients were classified into low (0-1) and high (2-4) NAPLES groups. Independent predictors were evaluated using multivariable logistic regression analysis.
RESULTS: Malignant ventricular arrhythmias were more common in patients with high NAPLES scores than in those with low scores (46.3% vs. 36.1%, p = 0.042). High NAPLES score was independently associated with malignant ventricular arrhythmias (OR: 2.00, 95% CI: 1.14-3.23, p = 0.027). Each one-point increase in NAPLES score was also associated with increased arrhythmic risk (OR: 1.40, 95% CI: 1.08-1.81, p = 0.018).
CONCLUSION: The NAPLES score is independently associated with malignant ventricular arrhythmias and may aid arrhythmic risk stratification in patients with cardiomyopathy and CIEDs.