Contraception · 2025
Potassium chloride intracardiac fetal injection and tissue degeneration at fetal autopsy following induction abortion.
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Chui Kelvin, Terry Jefferson, Hutcheon Jennifer A, Mayer Chantal, Liauw Jessica
Аннотация
OBJECTIVES: To assess the impact of potassium chloride intracardiac injection (KCl) on tissue degeneration at fetal autopsy, which may help inform termination care and autopsy expectations.
STUDY DESIGN: In this retrospective cohort of induction abortions with fetal autopsies (N = 266), we estimated the association between KCl and fetal tissue degeneration (qualitative assessment and quantitative ratio of basophilia:eosinophilia). We used log binomal and linear regression to calculate risk ratios and mean differences with 95% confidence intervals.
RESULTS: Those who received KCl were more likely to have qualitative tissue degeneration than those who did not (RR 2.8 [95% CI 1.3-6.1]). Quantitative basophilia:eosinophilia ratios were lower among those with KCl (mean difference in cardiac tissues of -0.031 [95% CI -0.039 to -0.023]), which further supports increased tissue degeneration in these cases.
CONCLUSIONS: Fetal autopsies from induction abortions that had KCl fetal injection had increased risk of tissue degeneration compared with those that did not.
STUDY DESIGN: In this retrospective cohort of induction abortions with fetal autopsies (N = 266), we estimated the association between KCl and fetal tissue degeneration (qualitative assessment and quantitative ratio of basophilia:eosinophilia). We used log binomal and linear regression to calculate risk ratios and mean differences with 95% confidence intervals.
RESULTS: Those who received KCl were more likely to have qualitative tissue degeneration than those who did not (RR 2.8 [95% CI 1.3-6.1]). Quantitative basophilia:eosinophilia ratios were lower among those with KCl (mean difference in cardiac tissues of -0.031 [95% CI -0.039 to -0.023]), which further supports increased tissue degeneration in these cases.
CONCLUSIONS: Fetal autopsies from induction abortions that had KCl fetal injection had increased risk of tissue degeneration compared with those that did not.