Update on the management of acute liver failure.

PURPOSE OF REVIEW: Acute liver failure (ALF) is a rare, life-threatening but potentially reversible clinical syndrome characterized by multiple organ failure secondary to the rapid loss of liver function. Key management challenges include severe cerebral oedema and complex treatments to support multiple organ failure. This review focuses on the fundamental principles of management and recent treatment advances.

RECENT FINDINGS: Identifying the cause of ALF is key to guiding specific therapies. The early commencement of continuous renal replacement therapy (CRRT) to control hyperammonaemia can now be considered an important standard of care, and plasma exchange may have a role in the sickest of ALF patients; however, other blood purification modalities still lack supporting evidence. Close monitoring, regular investigations, careful attention to neuroprotective measures, as well as optimizing general physiological supports is essential. Where possible, patients should be transferred to a liver transplant centre to achieve the best chance of transplant-free survival, or to undergo emergency liver transplantation if required.

SUMMARY: This review outlines current principles of ALF management, emerging treatment strategies, and a practical approach to management in the ICU. These recommendations can form the development of local guidelines, incorporating current best evidence for managing this rare but often lethal condition.