[Expression of TNF alpha and VCAM-1 in nasal polyps and relation with eosinophil infiltration].

OBJECTIVE

To study the expression of TNF alpha and VCAM-1 in nasal polyps tissue and its significance.

METHOD: Paraffin sections of nasal polyps and chronic rhinitis samples were studied with immunohistochemical technique.

RESULT: Expression of TNF alpha and VCAM-1 were stranger in nasal polyps tissues than in controls. There was positive relationship between the expression of TNF alpha and that of VCAM-1(r = 0.833), and expression of VCAM-1 coincide with eosinophil infiltration(r = 0.746).

CONCLUSION

It is suggested that TNF alpha may up-regulate the expression of VCAM-1 in vessel endothelium, and prompt adhesion and migration of eosinophils, TNF alpha and VCAM-1 may play important role in the pathogenesis of nasal polyps.