A Rare Case of a Giant Parathyroid Adenoma in a Young Male Patient.

A giant parathyroid adenoma (GPTA) is a rare type of primary hyperparathyroidism (PHPT) characterized by a weight of at least 3.5 g. We report a case of a 24-year-old male patient who presented with generalized fatigue and pathological left humeral fracture, found to have a serum calcium level of 16.9 mg/dL and a parathyroid hormone (PTH) level of 3,164 pg/mL. A 5.4 g right inferior type E parathyroid adenoma was excised with normalization of PTH levels. His clinical course was complicated by hungry bone syndrome and required management by a multidisciplinary team involving internal medicine, endocrinology, endocrine surgery, orthopedic surgery, nephrology, thoracic surgery, and genetics.