Nature communications · 2018

The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди

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Park Se Eun, Pham Duy Thanh, Boinett Christine, Wong Vanessa K, Pak Gi Deok, Panzner Ursula, Espinoza Ligia Maria Cruz, von Kalckreuth Vera, Im Justin, Schütt-Gerowitt Heidi, Crump John A, Breiman Robert F, Adu-Sarkodie Yaw, Owusu-Dabo Ellis, Rakotozandrindrainy Raphaël, Soura Abdramane Bassiahi, Aseffa Abraham, Gasmelseed Nagla, Keddy Karen H, May Jürgen, Sow Amy Gassama, Aaby Peter, Biggs Holly M, Hertz Julian T, Montgomery Joel M, Cosmas Leonard, Olack Beatrice, Fields Barry, Sarpong Nimako, Razafindrabe Tsiriniaina Jean Luco, Raminosoa Tiana Mirana, Kabore Leon Parfait, Sampo Emmanuel, Teferi Mekonnen, Yeshitela Biruk, El Tayeb Muna Ahmed, Sooka Arvinda, Meyer Christian G, Krumkamp Ralf, Dekker Denise Myriam, Jaeger Anna, Poppert Sven, Tall Adama, Niang Aissatou, Bjerregaard-Andersen Morten, Løfberg Sandra Valborg, Seo Hye Jin, Jeon Hyon Jin, Deerin Jessica Fung, Park Jinkyung, Konings Frank, Ali Mohammad, Clemens John D, Hughes Peter, Sendagala Juliet Nsimire, Vudriko Tobias, Downing Robert, Ikumapayi Usman N, Mackenzie Grant A, Obaro Stephen, Argimon Silvia, Aanensen David M, Page Andrew, Keane Jacqueline A, Duchene Sebastian, Dyson Zoe, Holt Kathryn E, Dougan Gordon, Marks Florian, Baker Stephen

Аннотация

There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa.

Предметные рубрики MeSH

Africa South of the Sahara Anti-Bacterial Agents Drug Resistance, Multiple, Bacterial Genetic Variation Genotype Humans Incidence Phylogeny Phylogeography Salmonella Infections Salmonella typhi Typhoid Fever

The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH