Human immunology · 2008
Characterization of the presence and distribution of Foxp3(+) cells in chagasic patients with and without megacolon.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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da Silveira Alexandre B M, de Araújo Fernanda Fortes, Freitas Michelle A Ribeiro, Gomes Juliana Assis Silva, Chaves Ana Thereza, de Oliveira Enio C, Neto Salustiano G, Luquetti Alejandro O, da Cunha Souza Gilmar, Bernardino Júnior Roberto, Fujiwara Ricardo, d'Avila Reis Débora, Correa-Oliveira Rodrigo
Аннотация
Patients with Chagas's disease in the chronic phase regularly present with the chagasic megacolon. This form is characterized by inflammation, neuronal destruction, and organ dilatation. Chagasic patients with megacolon always present with inflammatory process near the enteric plexuses of the colon, as previously demonstrated. The aim of this study is to characterize the presence and distribution of Foxp3(+) cells in the muscle layers and neuronal plexuses area of the colon from chagasic patients with and without megacolon. Our results demonstrated that chagasic patients without megacolon presented with an increased concentration of Foxp3(+) cells in all colon layers compared with chagasic patients with megacolon and noninfected individuals. These cells were situated mainly near the blood vessels and rarely were associated with the inflammatory foci. We believe that the presence of Foxp3(+) cells may help to control the inflammatory process through the management of lymphocyte migration and, consequently, prevent neuronal destruction and chagasic megacolon development.