Conidiobolus spp.: A Rare Pathogen Causing Rhino-Facial Entomophthoramycosis: A Case Series.

Rhinofacial entomophthoramycosis is a rare chronic fungal infection caused by Conidiobolus spp., primarily affecting the nasal and facial regions of immunocompetent individuals in tropical and subtropical areas. This case series describes five patients diagnosed with this condition over three years at a district hospital. Patients presented with progressive rhinofacial swelling, nasal obstruction, and eosinophilia. Diagnosis was confirmed through fungal cultures on Sabouraud Dextrose Agar and Lactophenol Cotton Blue mounts, which identified characteristic conidia. Treatment included potassium iodide with cotrimoxazole or itraconazole, administered for 7-12 weeks. All patients responded well to therapy, with no recurrences observed during follow-ups lasting up to 8 months. This study emphasizes the importance of early diagnosis and awareness of this condition to prevent severe morbidity and facial disfigurement.