Overlap of Primary Biliary Cholangitis and Systemic Sclerosis: A Case of Reynolds Syndrome.

Reynolds Syndrome should be suspected in CREST patients with persistent cholestatic liver enzymes, since delayed diagnosis allows portal hypertension and variceal bleeding to develop. Early anti-mitochondrial antibody screening and prompt ursodeoxycholic acid therapy improve outcomes, and these patients need multidisciplinary follow-up for lung and thyroid disease.