Medicine · 2025
A case report of extranodal NK/T cell lymphoma nasal-type with direct pulmonary involvement.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Zhang Hui, Yin Jiaming, Ge Haibo
Аннотация
RATIONALE: Extranodal nasal-type NK/T-cell lymphoma primarily invades the nasal and nasopharyngeal regions, while direct pulmonary involvement is extremely rare and prone to clinical misdiagnosis or oversight.
PATIENT CONCERNS: A 45-year-old man presented with recurrent high fever and cough. Anti-infective therapy and the peaspartase + methotrexate + etoposide + dexamethasone regimen proved ineffective, with chest CT demonstrating disease progression.
DIAGNOSES: A patient with extranodal nasal-type NK/T-cell lymphoma, classified as stage IV group B refractory category, predominantly presenting with lung infiltration and concurrent multiorgan involvement of the bone marrow and adrenal glands is described herein.
INTERVENTIONS: The disease was controlled only after timely adjustment to a gemcitabine combined with oxaliplatin + PD-1 inhibitor chemotherapy regimen.
OUTCOMES: The patient now remains clinically stable with adequate oral intake and satisfactory sleep quality.
LESSONS: Clinicians should broaden diagnostic considerations and pay greater attention to heterogeneous tumors. For patients presenting with persistent recurrent fever, pulmonary consolidation lesions, and poor response to anti-infective therapy, prompt percutaneous lung biopsy should be performed to obtain pathological confirmation.
PATIENT CONCERNS: A 45-year-old man presented with recurrent high fever and cough. Anti-infective therapy and the peaspartase + methotrexate + etoposide + dexamethasone regimen proved ineffective, with chest CT demonstrating disease progression.
DIAGNOSES: A patient with extranodal nasal-type NK/T-cell lymphoma, classified as stage IV group B refractory category, predominantly presenting with lung infiltration and concurrent multiorgan involvement of the bone marrow and adrenal glands is described herein.
INTERVENTIONS: The disease was controlled only after timely adjustment to a gemcitabine combined with oxaliplatin + PD-1 inhibitor chemotherapy regimen.
OUTCOMES: The patient now remains clinically stable with adequate oral intake and satisfactory sleep quality.
LESSONS: Clinicians should broaden diagnostic considerations and pay greater attention to heterogeneous tumors. For patients presenting with persistent recurrent fever, pulmonary consolidation lesions, and poor response to anti-infective therapy, prompt percutaneous lung biopsy should be performed to obtain pathological confirmation.