Bone marrow transplantation · 2023
Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT).
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Mohty Mohamad, Malard Florent, Alaskar Ahmed S, Aljurf Mahmoud, Arat Mutlu, Bader Peter, Baron Frederic, Bazarbachi Ali, Blaise Didier, Brissot Eolia, Ciceri Fabio, Corbacioglu Selim, Dalle Jean-Hugues, Dignan Fiona, Huynh Anne, Kenyon Michelle, Nagler Arnon, Pagliuca Antonio, Perić Zinaida, Richardson Paul G, Ruggeri Annalisa, Ruutu Tapani, Yakoub-Agha Ibrahim, Duarte Rafael F, Carreras Enric
Аннотация
Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). A new definition for diagnosis, and a severity grading system for SOS/VOD in adult patients, was reported a few years ago on behalf of the European Society for Blood and Marrow Transplantation (EBMT). The aim of this work is to update knowledge regarding diagnosis and severity assessment of SOS/VOD in adult patients, and also its pathophysiology and treatment. In particular, we now propose to refine the previous classification and distinguish probable, clinical and proven SOS/VOD at diagnosis. We also provide an accurate definition of multiorgan dysfunction (MOD) for SOS/VOD severity grading based on Sequential Organ Failure Assessment (SOFA) score.