Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Regional astrocyte dysregulation and altered glymphatic-related markers in Alzheimer's disease frontal cortex.
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Alexopoulos Harry, Louka Xanthippi P, De Natale Edoardo Rosario, Koutroubi Kelly, Cashmore Lisa, Panayotacopoulou Maria T, Trougakos Ioannis P, Wilson Heather, Politis Marios
Аннотация
INTRODUCTION: Astrocyte dysfunction is central to Alzheimer's disease (AD), yet expression patterns of astrocytic markers remain poorly defined. We measured Aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) in post-mortem frontal cortex of AD patients and controls across BrainNet Europe (BNE) stages.
METHODS: We assessed marker expression across gray and white matter with immunohistochemistry and immunofluorescence.
RESULTS: In AD, gray-matter AQP4 area-fraction did not differ significantly overall by immunohistochemistry, while a stage-dependent increase emerged by BNE VI in both gray and white matter. AQP4/amyloid-β (Aβ) and AQP4/tau ratios were significantly reduced, consistent with reduced AQP4 retention relative to local proteinopathy burden. GFAP intensity was significantly decreased in both gray and white matter of AD patients, with disorganized peri-plaque morphology in gray matter.
DISCUSSION: These findings reveal compartment- and stage-specific astrocytic dysregulation in AD frontal cortex and identify local loss of AQP4 around proteinopathy. They support investigation of astrocyte/glymphatic-related pathways as biomarkers and therapeutic targets.
METHODS: We assessed marker expression across gray and white matter with immunohistochemistry and immunofluorescence.
RESULTS: In AD, gray-matter AQP4 area-fraction did not differ significantly overall by immunohistochemistry, while a stage-dependent increase emerged by BNE VI in both gray and white matter. AQP4/amyloid-β (Aβ) and AQP4/tau ratios were significantly reduced, consistent with reduced AQP4 retention relative to local proteinopathy burden. GFAP intensity was significantly decreased in both gray and white matter of AD patients, with disorganized peri-plaque morphology in gray matter.
DISCUSSION: These findings reveal compartment- and stage-specific astrocytic dysregulation in AD frontal cortex and identify local loss of AQP4 around proteinopathy. They support investigation of astrocyte/glymphatic-related pathways as biomarkers and therapeutic targets.