Biochemical and biophysical research communications · 2018
A combination of irinotecan/cisplatinum and irinotecan/temozolomide or tumor-targeting Salmonella typhimurium A1-R arrest doxorubicin- and temozolomide-resistant myxofibrosarcoma in a PDOX mouse model.
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Kiyuna Tasuku, Tome Yasunori, Murakami Takashi, Miyake Kentaro, Igarashi Kentaro, Kawaguchi Kei, Oshiro Hiromichi, Higuchi Takashi, Miyake Masuyo, Sugisawa Norihiko, Zhang Zhiying, Razmjooei Sahar, Wangsiricharoen Sintawat, Chmielowski Bartosz, Nelson Scott D, Russell Tara A, Dry Sarah M, Li Yunfeng, Eckardt Mark A, Singh Arun S, Chawla Sant, Kanaya Fuminori, Eilber Fritz C, Singh Shree Ram, Zhao Ming, Hoffman Robert M
Аннотация
Myxofibrosarcoma (MFS) is the most common sarcomas in elderly patients and is either chemo-resistant or recurs with metastasis after chemotherapy. This recalcitrant cancer in need of improved treatment. We have established a patient-derived orthotopic xenograft (PDOX) of MFS. The MFS PDOX model was established in the biceps femoris of nude mice and randomized into 7 groups of 7 mice each: control; doxorubicin (DOX); pazopanib (PAZ); temozolomide (TEM); Irinotecan (IRN); IRN combined with TEM; IRN combined with cisplatinum (CDDP) and Salmonella typhimurium A1-R (S. typhimurium A1-R). Treatment was evaluated by relative tumor volume and relative body weight. The MFS PDOX models were DOX, PAZ, and TEM resistant. IRN combined with TEM and IRN combined with CDDP were most effective on the MFS PDOX. S. typhimurium A1-R arrested the MFS PDOX tumor. There was no significant body weight loss in any group. The present study suggests that the combination of IRN with either TEM or CDDP, and S. typhimurium have clinical potential for MFS.