Cancer reports (Hoboken, N.J.) · 2025
Primary Mediastinal Germ Cell Tumor With Bone Marrow Infiltration: A Case Report and Literature Review.
СтатьяКлинический случайОбзорНазвание и аннотация: Перевод в очереди
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Rioja Patricia, Valencia Guillermo, Morante Zaida, Cruz Renier, Vidaurre Tatiana, Neciosup Silvia
Аннотация
INTRODUCTION: Bone marrow infiltration is a rare presentation in patients with extragonadal germinal cell tumors (EGGCTs). We report a case of primary mediastinal germ cell tumor presenting with bone marrow metastases.
CASE PRESENTATION: A 28-year-old male patient was admitted to Instituto Nacional de Enfermedades Neoplásicas with superior vena cava syndrome and a mediastinal mass accompanied by positive blood tumor markers for germinal cell tumor (GCT). In addition, he exhibited anemia and thrombocytopenia; therefore, bone marrow aspiration and biopsy were done and showed metastatic GCT cells. The patient started standard chemotherapy (bleomycin-etoposide-cisplatin) for 2 cycles; there was a reduction of serum tumor markers; however, the patient subsequently developed febrile neutropenia and severe pneumonia, resulting in death.
CONCLUSION: This case demonstrates an uncommon presentation of EGGCT with bone marrow metastases. Early detection of this presentation will help to reduce the tumor burden and the mortality associated with it.
CASE PRESENTATION: A 28-year-old male patient was admitted to Instituto Nacional de Enfermedades Neoplásicas with superior vena cava syndrome and a mediastinal mass accompanied by positive blood tumor markers for germinal cell tumor (GCT). In addition, he exhibited anemia and thrombocytopenia; therefore, bone marrow aspiration and biopsy were done and showed metastatic GCT cells. The patient started standard chemotherapy (bleomycin-etoposide-cisplatin) for 2 cycles; there was a reduction of serum tumor markers; however, the patient subsequently developed febrile neutropenia and severe pneumonia, resulting in death.
CONCLUSION: This case demonstrates an uncommon presentation of EGGCT with bone marrow metastases. Early detection of this presentation will help to reduce the tumor burden and the mortality associated with it.