Cancer reports (Hoboken, N.J.) · 2026
Pleomorphic Carcinoma With EGFR and Concomitant Mutations Transformed From Lung Adenocarcinoma: A Case Report.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Akazawa Yuki, Sato Takashi, Yagami Yuri, Kesen Yurika, Furo Tomohiro, Watanabe Atsuko, Endo Jumpei, Nakano Maito, Kurata Hiroto, Matsuo Hiromi, Nakahara Yoshiro, Sasaki Jiichiro, Naoki Katsuhiko
Аннотация
BACKGROUND: Transformation to small cell carcinoma, squamous cell carcinoma, and rarely, pleomorphic carcinoma (PC) has been reported to be found in EGFR-mutated lung cancer with acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). However, evidence for underlying factors including genomic profiles associated with PC transformation has been lacking.
CASE: We report a case of EGFR-mutated lung adenocarcinoma that transformed to PC confirmed by an autopsy after stereotactic radiotherapy and treatment with EGFR-TKIs. Comprehensive genomic profiling of the autopsy tissue revealed BRAF G466A, KRAS L19F, and NF1 Q2324* mutations in addition to EGFR E746_A750del. Anti-cancer treatments with radiation and EGFR-TKIs accompanying these gene alterations might induce the histological transformation and resistance to EGFR-TKIs.
CONCLUSION: This report adds an insight into the involvement of genetic events in histological transformation in EGFR-mutated lung cancer.
CASE: We report a case of EGFR-mutated lung adenocarcinoma that transformed to PC confirmed by an autopsy after stereotactic radiotherapy and treatment with EGFR-TKIs. Comprehensive genomic profiling of the autopsy tissue revealed BRAF G466A, KRAS L19F, and NF1 Q2324* mutations in addition to EGFR E746_A750del. Anti-cancer treatments with radiation and EGFR-TKIs accompanying these gene alterations might induce the histological transformation and resistance to EGFR-TKIs.
CONCLUSION: This report adds an insight into the involvement of genetic events in histological transformation in EGFR-mutated lung cancer.