Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification by the ENIGMA PTSD Consortium.
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Suarez-Jimenez Benjamin, Lazarov Amit, Zhu Xi, Zilcha-Mano Sigal, Kim Yoojean, Marino Claire E, Rjabtsenkov Pavel, Bavdekar Shreya Y, Pine Daniel S, Bar-Haim Yair, Larson Christine L, Huggins Ashley A, Terri deRoon-Cassini, Tomas Carissa, Fitzgerald Jacklynn, Kennis Mitzy, Varkevisser Tim, Geuze Elbert, Quidé Yann, El Hage Wissam, Wang Xin, O'Leary Erin N, Cotton Andrew S, Xie Hong, Shih Chiahao, Disner Seth G, Davenport Nicholas D, Sponheim Scott R, Koch Saskia B J, Frijling Jessie L, Nawijn Laura, van Zuiden Mirjam, Olff Miranda, Veltman Dick J, Gordon Evan M, May Geoffery, Nelson Steven M, Jia-Richards Meilin, Neria Yuval, Morey Rajendra A
Аннотация
METHODS: Data were collected from 9 sites taking part in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) PTSD Consortium (n= 584) and included itemized PTSD symptom scores and resting-state functional connectivity (rsFC) data. We assessed the utility of rsFC in classifying PTSD, ITRED-only (no PTSD diagnosis), and trauma-exposed (TE)-only (no PTSD or ITRED) groups using a machine learning approach, examining well-known networks implicated in PTSD. A random forest classification model was built on a training set using cross-validation, and the averaged cross-validation model performance for classification was evaluated using the area under the curve. The model was tested using a fully independent portion of the data (test dataset), and the test area under the curve was evaluated.
RESULTS: rsFC signatures differentiated TE-only participants from PTSD and ITRED-only participants at about 60% accuracy. Conversely, rsFC signatures did not differentiate PTSD from ITRED-only individuals (45% accuracy). Common features differentiating TE-only participants from PTSD and ITRED-only participants mainly involved default mode network-related pathways. Some unique features, such as connectivity within the frontoparietal network, differentiated TE-only participants from one group (PTSD or ITRED-only) but to a lesser extent from the other group.
CONCLUSIONS: Neural network connectivity supports ITRED as a novel neurobiologically based approach to classifying posttrauma psychopathology.