Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke · 2026
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СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод в очереди
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Berdal-Sanner Kaja, Andvik Sarah K K, Müller Bernd, Riisnes Idunn O, Holsen Dag Sollesnes
Аннотация
BACKGROUND: Calciphylaxis is a rare and life-threatening disease characterised by calcification and occlusion of arterioles in the dermis and subcutis, leading to painful reticular purpura, necrosis and ulceration. Mortality ranges from 50% to 80% and septicaemia is the usual cause of death. End-stage kidney failure and haemodialysis are the most important risk factors. Calciphylaxis is also reported in patients with non-uraemic causes.
CASE PRESENTATION: We present a man in his forties who developed painful reticular purpura and necrotic ulcerations on the proximal lower extremities following alcohol-induced multi-organ failure, including acute renal failure. Skin biopsy results suggested calciphylaxis. The patient received hyperbaric oxygen therapy and vacuum-assisted ulcer treatment, followed by surgical debridement and split-thickness skin grafts.
INTERPRETATION: A multidisciplinary approach is necessary to achieve the best patient outcome. We believe that important factors contributing to this patient's outcome were his young age and early normalisation of renal function.
CASE PRESENTATION: We present a man in his forties who developed painful reticular purpura and necrotic ulcerations on the proximal lower extremities following alcohol-induced multi-organ failure, including acute renal failure. Skin biopsy results suggested calciphylaxis. The patient received hyperbaric oxygen therapy and vacuum-assisted ulcer treatment, followed by surgical debridement and split-thickness skin grafts.
INTERPRETATION: A multidisciplinary approach is necessary to achieve the best patient outcome. We believe that important factors contributing to this patient's outcome were his young age and early normalisation of renal function.