Journal of oral rehabilitation · 2026
Multiparametric Ultrasonographic Phenotyping of the Masseter Muscle in Temporomandibular Disorders and Clinically Defined Probable Bruxism.
СтатьяНазвание и аннотация: Перевод в очереди
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Tekin Alperen, Arsan Özcan Belde, Sümer Burcu, Erdoğan Büşra
Аннотация
BACKGROUND: Temporomandibular disorders (TMDs) and bruxism-related masticatory muscle activity may influence masseter morphology, mechanical response and B-mode texture, but their combined ultrasonographic phenotype is unclear.
OBJECTIVE: To evaluate whether clinically defined TMD status and probable bruxism-positive phenotype are associated with multiparametric masseter ultrasound profiles.
METHODS: This prospective single-centre study included 108 adults classified as TMD-negative/bruxism-negative controls (C0, n = 31), TMD-negative/probable bruxism-positive (T3, n = 25), TMD-positive/bruxism-negative (T2, n = 25) and TMD-positive/probable bruxism-positive (T1, n = 27). Sleep and awake bruxism were not separately distinguished. Bilateral thickness, cross-sectional-area-derived sonographic estimated volume, strain elastography and resting fractal dimension (FD) were analysed offline by a single observer blinded to group allocation.
RESULTS: After false-discovery-rate correction, four-group differences remained significant for resting/clenching thickness, estimated volume, strain elastography and resting FD (all q ≤ 0.001), with medium-to-large effects. T3 showed higher morphometric values, but sex-stratified and sex-adjusted analyses indicated that this finding required caution because of male predominance. GEE models identified sex, age, functional condition and group-by-condition terms as important determinants. FD repeatability was excellent (ICC [A,1] = 0.964; 95% CI, 0.941-0.977; coefficient of variation, 0.54%).
CONCLUSION: Multiparametric masseter ultrasonography may capture complementary morphology, strain-response and B-mode texture phenotypes in TMD and clinically defined probable bruxism. Findings should be interpreted as phenotype-enrichment rather than diagnostic evidence because TMD subtypes were heterogeneous and sleep/awake bruxism was not separately quantified.
OBJECTIVE: To evaluate whether clinically defined TMD status and probable bruxism-positive phenotype are associated with multiparametric masseter ultrasound profiles.
METHODS: This prospective single-centre study included 108 adults classified as TMD-negative/bruxism-negative controls (C0, n = 31), TMD-negative/probable bruxism-positive (T3, n = 25), TMD-positive/bruxism-negative (T2, n = 25) and TMD-positive/probable bruxism-positive (T1, n = 27). Sleep and awake bruxism were not separately distinguished. Bilateral thickness, cross-sectional-area-derived sonographic estimated volume, strain elastography and resting fractal dimension (FD) were analysed offline by a single observer blinded to group allocation.
RESULTS: After false-discovery-rate correction, four-group differences remained significant for resting/clenching thickness, estimated volume, strain elastography and resting FD (all q ≤ 0.001), with medium-to-large effects. T3 showed higher morphometric values, but sex-stratified and sex-adjusted analyses indicated that this finding required caution because of male predominance. GEE models identified sex, age, functional condition and group-by-condition terms as important determinants. FD repeatability was excellent (ICC [A,1] = 0.964; 95% CI, 0.941-0.977; coefficient of variation, 0.54%).
CONCLUSION: Multiparametric masseter ultrasonography may capture complementary morphology, strain-response and B-mode texture phenotypes in TMD and clinically defined probable bruxism. Findings should be interpreted as phenotype-enrichment rather than diagnostic evidence because TMD subtypes were heterogeneous and sleep/awake bruxism was not separately quantified.