Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 1995
Toxicity of intravitreal interferon alpha-2b in the rabbit.
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Kertes P J, Britton W A, Addison D J, Munro S M, Marshall D H, Leonard B C
Аннотация
OBJECTIVE: To investigate the toxicity of single doses of intravitreally administered interferon alpha-2b in the New Zealand white albino rabbit.
INTERVENTIONS: One eye each of six rabbits received an intravitreal injection of 1000, 10,000, 100,000, 500,000, 1 million or 2 million units of interferon alpha-2b reconstituted in 0.1 mL of balanced salt solution. The fellow eye of the first three rabbits received an intravitreal injection of the same volume of balanced salt solution.
OUTCOME MEASURES: Media opacities, toxic effects to the retina, optic nerve or other ocular structures.
RESULTS: The injection of 2 million units of interferon alpha-2b elicited an immediate dense vitreous haze that largely cleared within 24 hours as well as numerous intraretinal hemorrhages that were no longer visible 7 days after injection. Histopathological study of this eye 14 days after injection showed a diffuse mixed inflammatory cell infiltrate with retinal vacuolation and ganglion cell dropout. In the remaining eyes, to dosages of 1 million units, the agent produced no clinically or pathologically evident toxic ocular effects.
CONCLUSIONS: Interferon alpha-2b appears to be safe and well tolerated up to dosages of 1 million units.
INTERVENTIONS: One eye each of six rabbits received an intravitreal injection of 1000, 10,000, 100,000, 500,000, 1 million or 2 million units of interferon alpha-2b reconstituted in 0.1 mL of balanced salt solution. The fellow eye of the first three rabbits received an intravitreal injection of the same volume of balanced salt solution.
OUTCOME MEASURES: Media opacities, toxic effects to the retina, optic nerve or other ocular structures.
RESULTS: The injection of 2 million units of interferon alpha-2b elicited an immediate dense vitreous haze that largely cleared within 24 hours as well as numerous intraretinal hemorrhages that were no longer visible 7 days after injection. Histopathological study of this eye 14 days after injection showed a diffuse mixed inflammatory cell infiltrate with retinal vacuolation and ganglion cell dropout. In the remaining eyes, to dosages of 1 million units, the agent produced no clinically or pathologically evident toxic ocular effects.
CONCLUSIONS: Interferon alpha-2b appears to be safe and well tolerated up to dosages of 1 million units.