Association of bowel urgency, disease activity and disability in patients with inflammatory bowel disease: A cross-sectional study from the GETAID.
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Amiot Aurelien, Ahres Axel, Stefanescu Carmen, Meyer Antoine, Nachury Maria, Nancey Stéphane, Richard Nicolas, Allez Matthieu, Altwegg Romain, Laharie David, Serrero Mélanie, Franchimont Denis, Hupé Marianne, Fumery Mathurin, Vuitton Lucine, Nahon Stéphane, Gilletta Cyrielle, Rouillon Cléa, Nuzzo Alexandre, Berre Catherine Le, Caron Bénédicte, Buisson Anthony, Amil Morgane, Charkaoui Maëva, Cadiot Guillaume, Caillo Ludovic, Simon Marion, Reenaers Catherine, Hébuterne Xavier, Plastaras Laurianne, Atanasiu Calina, Kwiatek Sandy, Uzzan Mathieu, Pelletier Anne-Laure, Benezech Alban, Vidon Mathias, Goutorbe Felix, Geyl Sophie, Cellier Christophe, Montuclard Céline, Moussata Driffa, Seksik Philippe, GETAID-bowel-urgency-in-IBD study group
Аннотация
PATIENTS AND METHODS: We conducted a multicentre cross‑sectional study including adult patients with Crohn's disease (CD) and ulcerative colitis (UC). Patients completed self-administered questionnaires evaluating bowel urgency and IBD-related disability using the IBD-Disk questionnaire. Severe bowel urgency was defined as an IBD-disk bowel urgency subscore ≥6.
RESULTS: A total of 2,514 patients (1,715 with CD) were included. Severe bowel urgency was observed in 17.1% of patients with UC and in 20.4% of patients with CD, compared to 3.6% and 7.6%, respectively, in those in clinical remission according to PRO-2 criteria. In multivariate analysis in patients with UC, factors associated with severe bowel urgency were general well-being subscore ≥2 and abdominal pain subscore ≥2 while treatment with advanced therapy, clinical remission according to PRO-2, fatigue subscore <5, work productivity subscore <3 and sexual life subscore <2 were negatively associated. In patients with CD, factors were rectal bleeding subscore ≥2, abdominal pain subscore ≥2 and history of intestinal resection while clinical remission, fatigue subscore <5, work productivity subscore <3 and sexual life subscore <2 were negatively associated.
CONCLUSION: Severe bowel urgency is frequent in both patients with CD and UC beyond IBD activity and is strongly associated with various dimensions of IBD-related disability. These findings emphasise the importance of systematically assessing urgency in routine clinical practice.