[Treatment of hypothyroidism in childbearing age].

Thyroid diseases play a crucial role in conditions of infertility and recurrent miscarriages. We here reported a case of a 34 years old woman, affected by autoimmune thyroiditis with subclinical hypothyroidism. The patient previously had a miscarriage and she was planning another pregnancy. Therefore, she started levothyroxine (LT4) therapy. However, despite optimal TSH levels, she did not get pregnant and she underwent medically assisted procreation. During stimulation, TSH levels slightly increased and LT4 therapy has been increased to reach optimal TSH. After the conception, a monthly biochemical evaluation of the thyroid function test has been performed, with further adjustments of LT4 therapy, until the 30th week of pregnancy. In the post-partum period, LT4 therapy has been reduced and periodical biochemical evaluation has been performed. The case confirms the importance of the thyroid function evaluation during fertile age to obtain optimal TSH levels, with the aims to favorite the conception and to assure a favorable pregnancy outcome.