Current drug metabolism · 2026
Protective Role of Atriplex halimus L. Against Sodium Benzoate-Induced Fat Benzene Accumulation, Bone Marrow and Liver Alterations in Wistar Rats.
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Zeghib Khaoula, Boutlelis Djahra Ali, Laib Ibtissam, Menai Soumaia, Bouafia Abderrhmane, Nani Sadok, Rebiai Abdelkrim
Аннотация
INTRODUCTION/OBJECTIVE: This study evaluates the adverse effects of sodium benzoate on the bone marrow and liver of rats, its potential to form benzene, and the protective role of Atriplex halimus extract.
METHODS: Thirty male albino rats were divided into five groups: control, Atriplex halimus extract alone, sodium benzoate alone, sodium benzoate with preventive Atriplex halimus ex-tract, and sodium benzoate with curative Atriplex halimus extract. Sodium benzoate was administered in drinking water at a dose of 100 mg/kg body weight for 15 weeks. Atriplex halimus extract was administered intragastrically either during the final 30 days (curative) or throughout the entire sodium benzoate exposure period (preventive). Phytochemical analysis of the extract was conducted using LC-MS. Biochemical, histopathological, and oxidative stress markers were assessed.
RESULTS: Sodium benzoate exposure led to benzene detection in fat tissues, reduced neutrophil counts, altered hepatic enzyme levels (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase), decreased antioxidant defenses (glutathione, catalase, glutathione S-transferase), and increased malondialdehyde levels. Histopathological analysis revealed significant liver degeneration and milder bone marrow damage. Atriplex halimus extract restored biochemical and histological parameters, reversed neutropenia, and reduced benzene accumulation.
DISCUSSION: The findings confirm sodium benzoate's toxicity, particularly its oxidative stress and tissue damage effects, and highlight the protective potential of Atriplex halimus extract due to its phenolic compounds and saponins.
CONCLUSION: Atriplex halimus extract exhibits preventive and curative effects against sodium benzoate-induced benzene accumulation in fat, as well as bone marrow and liver injuries.
METHODS: Thirty male albino rats were divided into five groups: control, Atriplex halimus extract alone, sodium benzoate alone, sodium benzoate with preventive Atriplex halimus ex-tract, and sodium benzoate with curative Atriplex halimus extract. Sodium benzoate was administered in drinking water at a dose of 100 mg/kg body weight for 15 weeks. Atriplex halimus extract was administered intragastrically either during the final 30 days (curative) or throughout the entire sodium benzoate exposure period (preventive). Phytochemical analysis of the extract was conducted using LC-MS. Biochemical, histopathological, and oxidative stress markers were assessed.
RESULTS: Sodium benzoate exposure led to benzene detection in fat tissues, reduced neutrophil counts, altered hepatic enzyme levels (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase), decreased antioxidant defenses (glutathione, catalase, glutathione S-transferase), and increased malondialdehyde levels. Histopathological analysis revealed significant liver degeneration and milder bone marrow damage. Atriplex halimus extract restored biochemical and histological parameters, reversed neutropenia, and reduced benzene accumulation.
DISCUSSION: The findings confirm sodium benzoate's toxicity, particularly its oxidative stress and tissue damage effects, and highlight the protective potential of Atriplex halimus extract due to its phenolic compounds and saponins.
CONCLUSION: Atriplex halimus extract exhibits preventive and curative effects against sodium benzoate-induced benzene accumulation in fat, as well as bone marrow and liver injuries.