Peanut allergy in Italy: A unique Italian perspective.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Asero Riccardo, Nucera Eleonora, Rizzi Angela, Aruanno Arianna, Uasuf Carina G, Manzotti Giuseppina, Villalta Danilo, Conte Mariaelisabetta, Pastorello Elide A, Losappio Laura, Schroeder Jan V, Pinter Elena, Miglionico Marzia, Vantaggio Lorenzo, Macchia Donatella, Radice Anna, Marra Alessandro M, Barzaghi Claudio, Santucci Annalisa, Cortellini Gabriele, Peveri Silvia, Montagni Marcello, Demonte Antongiulio, Borrelli Paolo, Errico Micol A, Rivolta Federica, Pravettoni Valerio, Sangalli Andrea, Magnani Monica, Celi Giorgio, Yang Baoran, Costantino Maria T, Deleonardi Gaia, Boni Elisa, Gattoni Marco, Rizzini Fabio Lodi, Di Paolo Camilla, Montera Mariacarmela, Giordano Annaclaudia, De Carli Marco, Murzilli Francesco, Fumagalli Federica, Maffeis Laura, Ghiglioni Daniele Giovanni, Centonze Simone, Di Lizia Michela, Calafiore Paolo, Scala Enrico
Аннотация
OBJECTIVE: Our aim was to better define the clinical features of peanut allergy in Italy and to detect the peanut proteins involved in allergic reactions.
METHODS: A total of 22 centers participated in a prospective survey of peanut allergy over a 6-month period. Clinical histories were confirmed by in vivo and/or in vitro diagnostic means in all cases. Potential risk factors for peanut allergy occurrence were considered. Levels of IgE to Arachis hypogea (Ara h) 1, 2, 3, 6, 8, and 9 and profilin were measured.
RESULTS: A total of 395 patients (aged 2-80 years) were enrolled. Of the participants, 35% reported local reactions, 38.2% reported systemic reactions, and 26.6% experienced anaphylaxis. The sensitization profile was dominated by Ara h 9 (77% of patients were sensitized to it), whereas 35% were sensitized to pathogenesis-related protein 10 (PR-10) and 26% were sensitized to seed storage proteins (SSPs). Sensitization to 2S albumins (Ara h 2 and Ara h 6) or lipid transfer protein (LTP) was associated with the occurrence of more severe symptoms, whereas profilin and PR-10 sensitization were associated with milder symptoms. Cosensitization to profilin reduced the risk of severe reactions in both Ara h 2- and LTP-sensitized patients. SSP sensitization prevailed in younger patients whereas LTP prevailed in older patients (P < .01). SSP sensitization occurred mainly in northern Italy, whereas LTP sensitization prevailed in Italy's center and south. Atopic dermatitis, frequency of peanut ingestion, peanut consumption by other family members, or use of peanut butter did not seem to be risk factors for peanut allergy onset.
CONCLUSIONS: In Italy, peanut allergy is rare and dominated by LTP in the country's center and south and by SSP in the north. These 2 sensitizations seem mutually exclusive. The picture differs from that in Anglo-Saxon countries.