Journal of pharmacological sciences · 2025
Goreisan suppresses cardiac remodeling and dysfunction in a new mouse model with diabetic cardiomyopathy.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Funamoto Masafumi, Hirose Shunji, Yamamoto Mizuho, Du Ly-Nguyen Hai, Imanishi Masaki, Ebi Fuka, Ito Mai, Ohminami Hirokazu, Tsuchiya Koichiro, Ikeda Yasumasa
Аннотация
BACKGROUND: The global increase in diabetes, driven by aging populations and lifestyle changes, has led to an increase in the incidence of diabetic cardiomyopathy (DCM). DCM is characterized by metabolic abnormalities, oxidative stress, and inflammation, leading to cardiac remodeling and dysfunction. Goreisan (GRS), a traditional Japanese Kampo medicine, is commonly used to treat fluid control such as edema, due to its diuretic effect. In this study, we examined the effects of GRS on DCM.
METHODS: We first established a new mouse model of DCM and then evaluated the effects of GRS on DCM using a recently developed model.
RESULTS: The DCM mouse model developed cardiac hypertrophy, fibrosis, and dysfunction by nine weeks, which was ameliorated by GRS administration. GRS suppressed apoptosis and protein degradation by inhibiting Akt dephosphorylation and oxidative stress in DCM mice. In contrast, no differences in inflammatory cytokine levels were observed, regardless of GRS administration.
CONCLUSION: GRS has potential efficacy in preventing DCM onset and development.
METHODS: We first established a new mouse model of DCM and then evaluated the effects of GRS on DCM using a recently developed model.
RESULTS: The DCM mouse model developed cardiac hypertrophy, fibrosis, and dysfunction by nine weeks, which was ameliorated by GRS administration. GRS suppressed apoptosis and protein degradation by inhibiting Akt dephosphorylation and oxidative stress in DCM mice. In contrast, no differences in inflammatory cytokine levels were observed, regardless of GRS administration.
CONCLUSION: GRS has potential efficacy in preventing DCM onset and development.