Journal of cutaneous pathology · 2023
T follicular helper phenotype mycosis fungoides associated with acanthosis nigricans.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Spigariolo Cristina B, Berti Emilio, Cerri Amilcare, Venegoni Luigia, Croci Giorgio, Violetti Silvia Alberti
Аннотация
The association between acanthosis nigricans (AN) and mycosis fungoides (MF) has rarely been described, but it is known that MF may appear as AN-like vegetating and papillomatous plaques in skin folds, or may be associated with paraneoplastic AN. There have also been recent descriptions of a form of "intertriginous MF" that is characterized by skin fold involvement and the expression of T follicular helper (TFH) markers, and that often has an aggressive course. We describe the case of a 48-year-old man affected by MF associated with AN, whose lesions were characterized by a TFH immunophenotype and the expression of the GATA-3 nuclear master regulator that may be related to a TFH-2 subpopulation or possible disease progression.