The Journal of laryngology and otology · 2025
Evaluation of long-term low-dose antibiotic therapy as an adjunct to intra-nasal corticosteroids in the management of chronic rhinosinusitis with nasal polyps.
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Yıldırım Fatma, Eroglu Ergin, Basak Hatice
Аннотация
OBJECTIVES: This study evaluates the effectiveness of long-term, low-dose antibiotic treatment (macrolides and doxycycline) combined with intra-nasal corticosteroids in patients with chronic rhinosinusitis with nasal polyps.
METHODS: A total of 72 patients diagnosed with chronic rhinosinusitis with nasal polyps, aged 18-65, were followed for at least six months. Patients were randomized into three treatment groups: group 1 (intra-nasal corticosteroids and nasal saline irrigation), group 2 (intra-nasal corticosteroids, saline irrigation and macrolides) and group 3 (intra-nasal corticosteroids, saline irrigation and doxycycline).
RESULTS: Of the 72 patients, 43 (59.7 per cent) were male, and 29 (40.3 per cent) were female, with an average age of 48.69 plus or minus 15.71 years. A significant reduction in polyp stages was observed bilaterally and unilaterally in group 3 (p < 0.05). Lund-Mackay Score showed significant improvement in group 2 and group 3.
CONCLUSION: Adding doxycycline to intra-nasal corticosteroids therapy led to significant reductions in polyp stages and Lund-Mackay Score, suggesting potential clinical and radiological benefits.
METHODS: A total of 72 patients diagnosed with chronic rhinosinusitis with nasal polyps, aged 18-65, were followed for at least six months. Patients were randomized into three treatment groups: group 1 (intra-nasal corticosteroids and nasal saline irrigation), group 2 (intra-nasal corticosteroids, saline irrigation and macrolides) and group 3 (intra-nasal corticosteroids, saline irrigation and doxycycline).
RESULTS: Of the 72 patients, 43 (59.7 per cent) were male, and 29 (40.3 per cent) were female, with an average age of 48.69 plus or minus 15.71 years. A significant reduction in polyp stages was observed bilaterally and unilaterally in group 3 (p < 0.05). Lund-Mackay Score showed significant improvement in group 2 and group 3.
CONCLUSION: Adding doxycycline to intra-nasal corticosteroids therapy led to significant reductions in polyp stages and Lund-Mackay Score, suggesting potential clinical and radiological benefits.