Toothaches of Non-odontogenic Origin.

Nonodontogenic toothaches (NOTAs) are toothaches of nondental origin with etiologies including but not limited to myofascial, cardiac, neurovascular, trigeminal neuralgia, sinus origin, infections, drugs, systemic conditions, and psychogenic. Reproduction of the patient's chief complaint/familiar pain is crucial for the diagnosis of NOTAs. The site and source of pain are different. NOTAs can pose a real diagnostic challenge due to its presentation as a toothache, rendering unnecessary and irreversible treatment of the patients. Therefore, a thorough medical and travel history, clinical examination, imaging, laboratory investigations, diagnostic and pharmacologic testing are crucial for accurate diagnosis followed by an interdisciplinary management approach.