Characteristics and outcome of ambulatory heart failure patients receiving a left ventricular assist device.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Baudry Guillaume, Nesseler Nicolas, Flecher Erwan, Vincentelli André, Goeminne Céline, Delmas Clément, Porterie Jean, Nubret Karine, Pernot Mathieu, Kindo Michel, Hoang Minh Tam, Rouvière Philippe, Gaudard Philippe, Michel Magali, Senage Thomas, Boignard Aude, Chavanon Olivier, Para Marylou, Verdonk Constance, Pelcé Edeline, Gariboldi Vlad, Anselme Frederic, Litzler Pierre-Yves, Blanchart Katrien, Babatasi Gerard, Bielefeld Marie, Bouchot Olivier, Hamon David, Lellouche Nicolas, Bailleul Xavier, Genet Thibaud, Eschalier Romain, d'Ostrevy Nicolas, Bories Marie-Cécile, Akar Ramzi Abi, Blangy Hugues, Vanhuyse Fabrice, Obadia Jean François, Galand Vincent, Pozzi Matteo
Аннотация
METHODS AND RESULTS: The ASSIST-ICD registry collected LVAD data in 19 centres in France between February 2006 and December 2016. We used data of patients in Interagency Registry for Mechanically Assisted Circulatory Support Classes 4-7. The primary endpoint was survival analysis. Predictors of mortality were searched with multivariable analyses. A total of 303 patients (mean age 61.0 ± 9.9 years, male sex 86.8%) were included in the present analysis. Ischaemic cardiomyopathy was the leading heart failure aetiology (64%), and bridge to transplantation was the main implantation strategy (56.1%). The overall likelihood of being alive while on LVAD support or having a transplant at 1, 2, 3, and 5 years was 66%, 61.7%, 58.7%, and 55.1%, respectively. Age [hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.00-1.05; P = 0.02], a concomitant procedure (HR 2.32, 95% CI 1.52-3.53; P < 0.0001), and temporary mechanical right ventricular support during LVAD implantation (HR 2.94, 95% CI 1.49-5.77; P = 0.002) were the only independent variables associated with mortality. Heart failure medications before or after LVAD implantation were not associated with survival.
CONCLUSION: Ambulatory heart failure patients displayed unsatisfactory survival rates after LVAD implantation. A better selection of patients who can benefit from LVAD may help improving outcomes.