Real-world battery longevity of implantable loop recorders implanted for unexplained syncope: Results from a large single-center registry.

BACKGROUND/PURPOSE: Implantable loop recorders (ILR) are increasingly used in cardiac rhythm monitoring and diagnostic work-up of unexplained syncope. ILR battery longevity, according to manufacturers' product performance specifications, typically ranges between 2 and 4 years, but real-world data in this population are lacking.

METHODS

This monocentric, prospective, observational study included consecutive patients with unexplained syncope undergoing ILR implantation between October 2007 and 2019. The main purpose was to determine real-world battery longevity of ILRs. Diagnostic yield and relationship between arrhythmogenic diagnosis and duration of ILR monitoring were explored.

RESULTS

The study included 309 patients (59 years [38-73], 49% female) with ILR implantation for unexplained syncope. Median battery longevity was 42 [40-45] months. A total of 99.5% of ILRs reached prespecified battery longevity. The time to end-of-life varied by up to 33 months among the same ILR models. Overall arrhythmogenic diagnostic yield counted 27% (73% sick sinus syndrome, 20% atrioventricular block, and 7% ventricular tachycardia). Median time to diagnosis was 10 [2-25] months, with the latest event at 43 months. The cumulative diagnostic yield for arrhythmogenic event explaining syncope was 4.2%, 6.1%, 9.4%, 14.6%, 19.4%, and 26.7% at 1, 2, 6, 12, 24, and 48 months, respectively. In univariate analysis, first degree AV block and prolonged HV time on EP study were predictors of diagnosis, while QRS duration abnormality borderline missed significance.

CONCLUSIONS

Real-world battery longevity of ILRs matched industry projected longevity in 99.5% of patients implanted with ILR for unexplained syncope. A battery longevity of minimum 3.5 years is recommended to maximize the diagnostic yield in this population.