Journal of the Formosan Medical Association = Taiwan yi zhi · 2026
Clinical characteristics and peripheral immune profile analysis of thymoma-associated myasthenia gravis with anti-titin antibodies: a multicenter, retrospective study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Luo Yeting, Qiu Yusen, Chai Jingyan, Luo Si, Song Ziwei, Wu Xiangbin, Dai Tingmin, Zhou Meihong, Liu Xianghong, Hong Daojun
Аннотация
BACKGROUND AND PURPOSE: Thymoma-associated myasthenia gravis (TAMG) patients with anti-titin antibodies exhibit uncertain clinical and immunological relevance.
METHODS: We analyzed 91 TAMG patients (40 Titin + group, 51 Titin- group) treated between 2019 and 2025. Clinical features, severity scores, and peripheral immune markers were compared, and finally tested the correlation between the latter and severity.
RESULTS: Titin + group had higher rates of MGFA ≥ III (55.00% vs. 25.49%, p = 0.004) and elevated QMG bulbar scores [3.00 (0.75-3.00) vs. 0.00 (0.00-0.00), p = 0.002]. They also showed increased platelets (249.42 ± 61.98 vs. 224.20 ± 48.02 × 109/L, p = 0.033), monocytes (0.59 ± 0.27 vs. 0.46 ± 0.23 × 109/L, p = 0.018), and IL-1β [4.20 (1.85-12.06) vs. 1.13 (0.46-3.13) pg/mL, p = 0.009]. IL-6 correlated with MGFA class (r = 0.67, p = 0.004) and QMG respiratory scores (r = 0.70, p = 0.026); NLR with QMG (r = 0.60, p = 0.018) and MG-ADL (r = 0.53, p = 0.044); TNF-α (r = 0.86, p = 0.014) and IL-8 (r = 0.79, p = 0.036) with MG-QoL15; PLR with QMG gross motor (r = 0.53, p = 0.041) and bulbar scores (r = 0.58, p = 0.025); SII and IL-2 with QMG bulbar (r = 0.53, p = 0.046) and respiratory scores (r = 0.78, p = 0.040), respectively.
CONCLUSION: Anti-titin antibodies positive TAMG is associated with more severe disease-especially bulbar involvement. NLR, PLR, IL-2, IL-6, IL-8, and TNF-α are candidate biomarkers of severity.
METHODS: We analyzed 91 TAMG patients (40 Titin + group, 51 Titin- group) treated between 2019 and 2025. Clinical features, severity scores, and peripheral immune markers were compared, and finally tested the correlation between the latter and severity.
RESULTS: Titin + group had higher rates of MGFA ≥ III (55.00% vs. 25.49%, p = 0.004) and elevated QMG bulbar scores [3.00 (0.75-3.00) vs. 0.00 (0.00-0.00), p = 0.002]. They also showed increased platelets (249.42 ± 61.98 vs. 224.20 ± 48.02 × 109/L, p = 0.033), monocytes (0.59 ± 0.27 vs. 0.46 ± 0.23 × 109/L, p = 0.018), and IL-1β [4.20 (1.85-12.06) vs. 1.13 (0.46-3.13) pg/mL, p = 0.009]. IL-6 correlated with MGFA class (r = 0.67, p = 0.004) and QMG respiratory scores (r = 0.70, p = 0.026); NLR with QMG (r = 0.60, p = 0.018) and MG-ADL (r = 0.53, p = 0.044); TNF-α (r = 0.86, p = 0.014) and IL-8 (r = 0.79, p = 0.036) with MG-QoL15; PLR with QMG gross motor (r = 0.53, p = 0.041) and bulbar scores (r = 0.58, p = 0.025); SII and IL-2 with QMG bulbar (r = 0.53, p = 0.046) and respiratory scores (r = 0.78, p = 0.040), respectively.
CONCLUSION: Anti-titin antibodies positive TAMG is associated with more severe disease-especially bulbar involvement. NLR, PLR, IL-2, IL-6, IL-8, and TNF-α are candidate biomarkers of severity.