Do open garbage dumps play a role in canine rabies transmission in Biyem-Assi health district in Cameroon?

OBJECTIVE

This prospective case study investigated the new therapeutic paradigm of autologous gold-induced immunotherapy (Go ACT®) in the treatment of pollen-based allergies. The safety and clinical efficacy of Go ACT® were investigated by assessing patients in the first pollen season following treatment with Go ACT®.

PATIENTS AND

METHODS

In this prospective case study, patients were enrolled who had a proven pollen allergy and had been previously unsuccessfully treated with standard medication. Clinical improvement following Go ACT® treatment was analyzed using symptom scores, ARIA classification and symptom control. The data generated in the case study were compared to the data from the previous pre-treatment pollen season.

RESULTS

16 patients were included in this study. The treatment was well tolerated by all patients. On completion of the study all of the patients rated the tolerability of the treatment as either good or very good. Local reactions to the treatment were not seen. No Serious Adverse Events (SAEs) occurred. The symptom scores decreased significantly from the 2016 pollen season to the 2017 pollen season in patients who received Go ACT® treatment. Analysis of the ARIA classification showed that 81.0% of patients had persistent, moderate-to-severe rhinitis before treatment.  Following treatment 7.1% of patients had persistent, moderate-to-severe rhinitis. A total of 62.4% of patients in the study achieved symptom control. A total of 38.8% of patients required no symptomatic medication after Go ACT® treatment. The rhino-conjunctivitis score was significantly lower after the treatment.

CONCLUSIONS

This study has shown that Go ACT® treatment is safe, effective, well-tolerated and accepted by patients suffering from pollen allergy. The results of the symptom scores, RCAT, ARIA classification show that Go ACT® treatment elicits immediate beneficial effects during the pollen season under treatment and for the season following treatment.