British journal of clinical pharmacology · 2021
Clinical and echocardiographic characteristics after six months of sacubitril/valsartan in Chagas heart disease - A case series.
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Figueiredo Clara Salles, de Melo Rodrigo Morel Vieira, Viana Taina Teixeira, de Jesus Aline Grimaldi Queiroz, da Silva Tainara Cerqueira, da Silva Vitor Mamedio, de Carvalho William Neves, da Silva Daniela Nascimento Valame, Passos Luiz Carlos Santana
Аннотация
Chagas cardiomyopathy is the most prevalent non-ischaemic cardiomyopathy in Latin America, with high morbidity and mortality even today. Treatment of these patients is based on the use of medications for heart failure. This study evaluated a case series of patients with Chagas heart disease who used sacubitril/valsartan at a referral hospital for this disease in Brazil. After 6 months, there was a symptomatic improvement in these individuals assessed by the New York Heart Association (NYHA) functional class, with a 44.3% reduction in the absolute number of patients classified as III-IV in the period (P = 0.035), but without changes in the parameters on the echocardiogram for reverse ventricular remodelling. There was a high mortality rate and number of hospitalizations. These results emphasize the importance of studying the use of sacubitril/valsartan in Chagas heart disease to better describe its effectiveness considering the particularities of these individuals.