Evidence-Based Practice for Comprehensive Management of Pemphigus Skin Lesions: An Evidence Synthesis Review.

Objectives: To identify, evaluate, and synthesize best evidence-based practices for the comprehensive care and management of cutaneous lesions in Pemphigus patients, encompassing assessment, prevention, topical care, health education, and follow-up. This aims to provide evidence-based guidance for clinical practice. Methods: Guided by the "6S" evidence model, a systematic search was performed across multiple databases, guideline repositories, and professional organization websites. The literature published from the inception of each database up to 25 February 2025 was considered. Two researchers with training in evidence-based methods independently assessed the quality of included literature, extracted data, and synthesized the evidence. Results: A total of 14 publications were included, consisting of 1 clinical decision tool, 6 guidelines, 6 expert consensus documents, and 1 systematic review. From these, 24 evidence recommendations were summarized, organized into five key areas: management principles, skin assessment, lesion care, health education, and recurrence and follow-up. Conclusions: This review integrates current best evidence on skin lesion management in Pemphigus into a structured set of recommendations. The findings offer practical, evidence-based guidance for clinical practice and can support the development of standardized care protocols to improve patient outcomes.