L'Encephale · 2026
Measuring antidepressant side effects in military personnel - Clinical validation of the French version of the UKU-SERS-Pat Scale: A comparative study of patient and clinician ratings.
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Klause Louise, Catrin Edwige, Lahutte Bertrand, Baldacci Antoine, Saguin Emeric
Аннотация
INTRODUCTION: Antidepressants are widely used to treat depression, PTSD, and generalized anxiety disorder. However, the side effects of antidepressants, which may affect treatment adherence and patient prognosis, are challenging to manage due to their overlap with psychiatric symptoms. In the same way as in the general population, side effects seem to have an impact on compliance with antidepressant treatment in military personnel which in turn affects their health and operability. The Udvalg for Kliniske Undersøgelser (UKU) Side Effect Rating Scale for Clinicians (UKU-SERS-Clin) is a comprehensive tool for evaluating side effects but is time-consuming for clinical practice. The UKU-SERS-Pat, a self-assessment version, could provide a more efficient method for side effect detection.
OBJECTIVE: The present study aimed to translate and validate the UKU-SERS-Pat into French and assess its reliability and validity in patients with antidepressant prescription.
METHODS: Thirty-two military patients completed both the UKU-SERS-Pat and UKU-SERS-Clin scales 4-8 weeks after starting antidepressant treatment.
RESULTS: Spearman's correlations demonstrated strong agreement between UKU-SERS-Clin and UKU-SERS-Pat for psychic (ρ=0.671, P<0.001), neurological (ρ=0.737, P<0.001), and autonomic side effects (ρ=0.666, P<0.001). Patients tended to report side effects more frequently and severely than clinicians. Significant differences were noted for several items, including asthenia, failing memory, inner unrest and male sexual side effects (all P<0.01).
CONCLUSION: The study confirmed the validity of the French UKU-SERS-Pat, demonstrating strong correlations with the assessments of clinicians. This tool is particularly valuable for identifying side effects that patients may underreport during clinical interviews, such as sexual dysfunction, and side effects like weight gain, or altered alertness which are of particular concern among military personnel. Further research with larger samples and diverse populations is recommended to confirm these findings and explore the scale's applicability in different clinical contexts.
OBJECTIVE: The present study aimed to translate and validate the UKU-SERS-Pat into French and assess its reliability and validity in patients with antidepressant prescription.
METHODS: Thirty-two military patients completed both the UKU-SERS-Pat and UKU-SERS-Clin scales 4-8 weeks after starting antidepressant treatment.
RESULTS: Spearman's correlations demonstrated strong agreement between UKU-SERS-Clin and UKU-SERS-Pat for psychic (ρ=0.671, P<0.001), neurological (ρ=0.737, P<0.001), and autonomic side effects (ρ=0.666, P<0.001). Patients tended to report side effects more frequently and severely than clinicians. Significant differences were noted for several items, including asthenia, failing memory, inner unrest and male sexual side effects (all P<0.01).
CONCLUSION: The study confirmed the validity of the French UKU-SERS-Pat, demonstrating strong correlations with the assessments of clinicians. This tool is particularly valuable for identifying side effects that patients may underreport during clinical interviews, such as sexual dysfunction, and side effects like weight gain, or altered alertness which are of particular concern among military personnel. Further research with larger samples and diverse populations is recommended to confirm these findings and explore the scale's applicability in different clinical contexts.