Oncotarget · 2016
slanDCs/M-DC8+ cells constitute a distinct subset of dendritic cells in human tonsils [corrected].
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Özbakır Çağla, Ergün Deniz, Kaçar Pelin, Kahraman Çetin Berna, Özbakır Hıncal, Özer Arife, Güner Özenen Gizem, Akaslan Kara Aybüke, Orbatu Dilek, Bayram Nuri, Devrim İlker
Аннотация
BACKGROUND: Children diagnosed with preseptal cellulitis frequently require hospitalization, leading to both clinical management challenges and substantial healthcare-related costs. The condition often necessitates intravenous antibiotic therapy, radiological imaging, laboratory tests, consultations, and inpatient care, which collectively contribute to the overall economic burden. However, data on the clinical characteristics and cost distribution among pediatric patients remain limited. This study aimed to evaluate both the clinical and economic burden of preseptal cellulitis in hospitalized children and to identify the clinical factors influencing healthcare costs.
METHODS: This retrospective study included children aged 1 month to 18 years who were hospitalized with a diagnosis of preseptal cellulitis between January 2019 and December 2024. Patients were grouped according to age and presence of predisposing factors. Length of stay, total hospital costs, and cost components were analyzed based on clinical characteristics.
RESULTS: A total of 166 patients were included (mean age: 70.1 ± 46.9 months; 62% male). The most common findings were periorbital swelling (96.4%) and erythema (75.3%). Median length of stay was 5 days, with no significant differences by age, sex, or predisposing factors (p>0.05). However, a strong positive correlation was found between length of stay and total cost (rho=0.775, p<0.001). The total hospital expenditure was 25,412.95 USD, with antibiotics accounting for the largest share (48.3%). Sinusitis and odontogenic infections were significantly associated with higher costs (p=0.007 and p=0.030). In multivariable analysis, length of stay, age, and odontogenic infection emerged as independent determinants of total cost, with costs increasing by approximately 15% per additional hospital day, 0.2% per month of age, and 25% in the presence of odontogenic infection.
CONCLUSION: Developing standardized treatment protocols and promoting rational antibiotic use are critical for optimizing healthcare resource utilization and preventing antibiotic resistance.
METHODS: This retrospective study included children aged 1 month to 18 years who were hospitalized with a diagnosis of preseptal cellulitis between January 2019 and December 2024. Patients were grouped according to age and presence of predisposing factors. Length of stay, total hospital costs, and cost components were analyzed based on clinical characteristics.
RESULTS: A total of 166 patients were included (mean age: 70.1 ± 46.9 months; 62% male). The most common findings were periorbital swelling (96.4%) and erythema (75.3%). Median length of stay was 5 days, with no significant differences by age, sex, or predisposing factors (p>0.05). However, a strong positive correlation was found between length of stay and total cost (rho=0.775, p<0.001). The total hospital expenditure was 25,412.95 USD, with antibiotics accounting for the largest share (48.3%). Sinusitis and odontogenic infections were significantly associated with higher costs (p=0.007 and p=0.030). In multivariable analysis, length of stay, age, and odontogenic infection emerged as independent determinants of total cost, with costs increasing by approximately 15% per additional hospital day, 0.2% per month of age, and 25% in the presence of odontogenic infection.
CONCLUSION: Developing standardized treatment protocols and promoting rational antibiotic use are critical for optimizing healthcare resource utilization and preventing antibiotic resistance.