Frontiers in pediatrics · 2025
Diagnostic value of combined detection of pepsinogen, gastrin-17, and 13C-urea breath test in Helicobacter pylori-associated chronic gastritis in children: a multivariate analysis.
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Gao Yiyun, Liu Chuangui, Ouyang Kaishi, Li Siqi, Huang Weilin
Аннотация
BACKGROUND: This study evaluated the diagnostic efficacy of combining pepsinogen (PG I/II), gastrin-17 (G-17), and 13C-urea breath test (13C-UBT) for chronic gastritis in children using logistic regression and receiver operating characteristic (ROC) analysis.
METHODS: Between June 2018 and August 2023, 65 children with chronic gastritis and 50 healthy controls participated. Inclusion criteria for both groups: Age 6-12 years, chronic gastritis confirmed by endoscopy and histopathology for the gastritis group, and absence of GI symptoms for the control group. Exclusion criteria: Severe cardiopulmonary dysfunction, gastroduodenal surgery, recent use of PPIs/antibiotics, and H. pylori eradication therapy. Serum levels of PG I, PG II, and G-17 were determined by ELISA, and 13C-UBT was used to detect Helicobacter pylori (Hp) infection.
RESULTS: Combined detection showed significantly higher positive rates than individual PG I/II or G-17 tests (P < 0.05), but similar to 13C-UBT alone. Chronic gastritis patients had elevated PG I, and G-17 levels compared to controls (P < 0.05). Multivariate analysis identified PG I (OR = 1.048, P = 0.014), G-17 (OR = 1.943, P < 0.001), and 13C-UBT positivity (OR = 17.417, P < 0.001) as significant predictors. ROC analysis revealed AUCs of 0.692 (PG I), 0.594 (PG II), 0.782 (G-17), 0.808 (13C-UBT), and 0.844 (combined), with sensitivity ≥90.8% and specificity >78%.
CONCLUSION: The combined detection of PG I/II, G-17, and 13C-UBT shows strong diagnostic potential for Helicobacter pylori-associated chronic gastritis in children, offering enhanced diagnostic accuracy and a non-invasive tool for early screening and intervention.
METHODS: Between June 2018 and August 2023, 65 children with chronic gastritis and 50 healthy controls participated. Inclusion criteria for both groups: Age 6-12 years, chronic gastritis confirmed by endoscopy and histopathology for the gastritis group, and absence of GI symptoms for the control group. Exclusion criteria: Severe cardiopulmonary dysfunction, gastroduodenal surgery, recent use of PPIs/antibiotics, and H. pylori eradication therapy. Serum levels of PG I, PG II, and G-17 were determined by ELISA, and 13C-UBT was used to detect Helicobacter pylori (Hp) infection.
RESULTS: Combined detection showed significantly higher positive rates than individual PG I/II or G-17 tests (P < 0.05), but similar to 13C-UBT alone. Chronic gastritis patients had elevated PG I, and G-17 levels compared to controls (P < 0.05). Multivariate analysis identified PG I (OR = 1.048, P = 0.014), G-17 (OR = 1.943, P < 0.001), and 13C-UBT positivity (OR = 17.417, P < 0.001) as significant predictors. ROC analysis revealed AUCs of 0.692 (PG I), 0.594 (PG II), 0.782 (G-17), 0.808 (13C-UBT), and 0.844 (combined), with sensitivity ≥90.8% and specificity >78%.
CONCLUSION: The combined detection of PG I/II, G-17, and 13C-UBT shows strong diagnostic potential for Helicobacter pylori-associated chronic gastritis in children, offering enhanced diagnostic accuracy and a non-invasive tool for early screening and intervention.