Frontiers in medicine · 2026
Neuromyelitis optica spectrum disorder with painful tonic spasms as the first symptom: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhao Feng, Wang Yue, Gong Jiajun, Yu Linjie, Zhu Xiaolei
Аннотация
BACKGROUND: Painful tonic spasms (PTS) are an underrecognized initial manifestation of neuromyelitis optica spectrum disorder (NMOSD), presenting before classic neurological deficits in rare cases.
CASE PRESENTATION: A 51-year-old man presented with progressive right lower limb PTS lasting ≤10 s, spreading bilaterally and impairing mobility within 1 month. Neurological examination showed bilateral hyperreflexia and myoclonus. Spinal MRI revealed longitudinally extensive T2 hyperintensity and gadolinium enhancement at T1-T6 levels. Serum aquaporin-4 immunoglobulin G (AQP4-IgG) antibody was positive (1:100), while cerebrospinal fluid AQP4-IgG analysis was negative. Methylprednisolone (0.5 g/day for 3 days, tapered to oral prednisolone) and intravenous immunoglobulin (0.4 g/kg/day for 5 days) significantly reduced spasms. At discharge, he ambulated independently without PTS on prednisolone (60 mg/day), oxcarbazepine (450 mg twice daily), and baclofen (10 mg twice daily).
CONCLUSION: Isolated PTS serves as a potential harbinger of NMOSD, and early diagnosis and precise immunotherapy enables rapid symptom control and attack prevention.
CASE PRESENTATION: A 51-year-old man presented with progressive right lower limb PTS lasting ≤10 s, spreading bilaterally and impairing mobility within 1 month. Neurological examination showed bilateral hyperreflexia and myoclonus. Spinal MRI revealed longitudinally extensive T2 hyperintensity and gadolinium enhancement at T1-T6 levels. Serum aquaporin-4 immunoglobulin G (AQP4-IgG) antibody was positive (1:100), while cerebrospinal fluid AQP4-IgG analysis was negative. Methylprednisolone (0.5 g/day for 3 days, tapered to oral prednisolone) and intravenous immunoglobulin (0.4 g/kg/day for 5 days) significantly reduced spasms. At discharge, he ambulated independently without PTS on prednisolone (60 mg/day), oxcarbazepine (450 mg twice daily), and baclofen (10 mg twice daily).
CONCLUSION: Isolated PTS serves as a potential harbinger of NMOSD, and early diagnosis and precise immunotherapy enables rapid symptom control and attack prevention.