The British journal of psychiatry : the journal of mental science · 2015
Structural and functional brain changes in delusional disorder.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Vicens Victor, Radua Joaquim, Salvador Raymond, Anguera-Camós Maria, Canales-Rodríguez Erick J, Sarró Salvador, Maristany Teresa, McKenna Peter J, Pomarol-Clotet Edith
Аннотация
BACKGROUND: Delusional disorder has been the subject of very little investigation using brain imaging.
AIMS: To examine potential structural and/or functional brain abnormalities in this disorder.
METHOD: We used structural imaging (voxel-based morphometry, VBM) and functional imaging (during performance of the n-back task and whole-brain resting connectivity analysis) to examine 22 patients meeting DSM-IV criteria for delusional disorder and 44 matched healthy controls.
RESULTS: The patients showed grey matter reductions in the medial frontal/anterior cingulate cortex and bilateral insula on unmodulated (but not on modulated) VBM analysis, failure of de-activation in the medial frontal/anterior cingulate cortex during performance of the n-back task, and decreased resting-state connectivity in the bilateral insula.
CONCLUSIONS: The findings provide evidence of brain abnormality in the medial frontal/anterior cingulate cortex and insula in delusional disorder. A role for the former region in the pathogenesis of delusions is consistent with several other lines of evidence.
AIMS: To examine potential structural and/or functional brain abnormalities in this disorder.
METHOD: We used structural imaging (voxel-based morphometry, VBM) and functional imaging (during performance of the n-back task and whole-brain resting connectivity analysis) to examine 22 patients meeting DSM-IV criteria for delusional disorder and 44 matched healthy controls.
RESULTS: The patients showed grey matter reductions in the medial frontal/anterior cingulate cortex and bilateral insula on unmodulated (but not on modulated) VBM analysis, failure of de-activation in the medial frontal/anterior cingulate cortex during performance of the n-back task, and decreased resting-state connectivity in the bilateral insula.
CONCLUSIONS: The findings provide evidence of brain abnormality in the medial frontal/anterior cingulate cortex and insula in delusional disorder. A role for the former region in the pathogenesis of delusions is consistent with several other lines of evidence.