European heart journal. Cardiovascular Imaging · 2025
Stent frame deformation of self-expanding transcatheter heart valves in bicuspid aortic stenosis and impact on valve performance.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Tirado Conte Gabriela, Arslani Ketina, Zaid Syed, Khokhar Arif, Boiago Mauro, Costa Giulia, Bonnet Guillaume, Mylotte Darren, De Carlo Marco, McInerney Angela, Hovasse Thomas, Campante Teles Rui, Sudre Arnaud, Akodad Mariama, Brito João, Bieliauskas Gintautas, Mahfoud Felix, de Biase Chiara, Piazza Nicolo, Leroux Lionel, Van Mieghem Nicolas M, Tang Gilbert H L, Nombela-Franco Luis, Tchétché Didier, De Backer Ole
Аннотация
AIMS: To evaluate stent frame expansion and ellipticity of the Evolut™ transcatheter heart valve (THV) and its subsequent impact on valve performance in patients with bicuspid aortic stenosis (AS) using pre- and post-procedural cardiac computed tomography (CT). In transcatheter aortic valve implantation (TAVI) for native bicuspid AS, concerns arise regarding the risk for reduced stent frame expansion and increased ellipticity compared with valves implanted in tricuspid AS. The implications of stent frame under-expansion and eccentricity on THV performance remain unclear.
METHODS AND RESULTS: This multi-centre registry included patients with bicuspid AS who underwent TAVI using the self-expanding Evolut™ THV and who had pre- and post-TAVI CT. Stent frame expansion and ellipticity were assessed at the inflow (nodes 0-1) and leaflet level (nodes 5-6). THV performance was evaluated by assessing mean transprosthetic gradient, paravalvular leak, and hypoattenuated leaflet thickening. Among 175 patients included, the inflow level of the Evolut THV had greater stent frame under-expansion (79.9% ± 6.7% vs. 95.4% ± 3.1% and P < 0.001) and ellipticity (1.3 ± 0.3 vs. 1.2 ± 0.1 and P < 0.001) compared to the leaflet level. Leaflet level expansion was unaffected by expansion or ellipticity at the inflow level; however, leaflet level ellipticity increased significantly with inflow under-expansion <75% (P = 0.002) and inflow ellipticity ≥1.3 (P < 0.001). Neither inflow under-expansion nor ellipticity impacted hemodynamic valve performance or leaflet thickening at short-term follow-up.
CONCLUSION: The self-expanding Evolut™ THV demonstrates consistent valve performance in bicuspid AS. Stent frame under-expansion and ellipticity at the inflow level do not compromise valve haemodynamics or contribute to leaflet thickening at short-term follow-up.
METHODS AND RESULTS: This multi-centre registry included patients with bicuspid AS who underwent TAVI using the self-expanding Evolut™ THV and who had pre- and post-TAVI CT. Stent frame expansion and ellipticity were assessed at the inflow (nodes 0-1) and leaflet level (nodes 5-6). THV performance was evaluated by assessing mean transprosthetic gradient, paravalvular leak, and hypoattenuated leaflet thickening. Among 175 patients included, the inflow level of the Evolut THV had greater stent frame under-expansion (79.9% ± 6.7% vs. 95.4% ± 3.1% and P < 0.001) and ellipticity (1.3 ± 0.3 vs. 1.2 ± 0.1 and P < 0.001) compared to the leaflet level. Leaflet level expansion was unaffected by expansion or ellipticity at the inflow level; however, leaflet level ellipticity increased significantly with inflow under-expansion <75% (P = 0.002) and inflow ellipticity ≥1.3 (P < 0.001). Neither inflow under-expansion nor ellipticity impacted hemodynamic valve performance or leaflet thickening at short-term follow-up.
CONCLUSION: The self-expanding Evolut™ THV demonstrates consistent valve performance in bicuspid AS. Stent frame under-expansion and ellipticity at the inflow level do not compromise valve haemodynamics or contribute to leaflet thickening at short-term follow-up.