Different trajectories in upper limb and gross motor function in spinal muscular atrophy.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Coratti Giorgia, Pera Maria Carmela, Montes Jacqueline, Pasternak Amy, Scoto Mariacristina, Baranello Giovanni, Messina Sonia, Dunaway Young Sally, Glanzman Allan M, Duong Tina, De Sanctis Roberto, Mazzone Elena Stacy, Milev Evelin, Rohwer Annemarie, Civitello Matthew, Pane Marika, Antonaci Laura, Frongia Anna Lia, Sframeli Maria, Vita Gian Luca, DʼAmico Adele, Mizzoni Irene, Albamonte Emilio, Darras Basil T, Bertini Enrico, Sansone Valeria A, Bovis Francesca, Day John, Bruno Claudio, Muntoni Francesco, De Vivo Darryl C, Finkel Richard, Mercuri Eugenio
Аннотация
METHODS: The study was performed by cross-sectional and longitudinal reanalysis of previously published natural history data. The longitudinal analysis of the 12-mo changes also included the analysis of concordance between scales with changes grouped as stable (±2 points), improved (>+2) or declined (>-2).
RESULTS: Three hundred sixty-four patients were included in the cross-sectional analysis, showing different trends in score and point of slope change for the two scales. For type 2, the point of slope change was 4.1 y for the HFMSE and 5.8 for the RULM, while for type 3, it was 6 y for the HFMSE and 7.3 for the RULM. One-hundred-twenty-one patients had at least two assessments at 12 mo. Full concordance was found in 57.3% of the assessments, and in 40.4% one scale remained stable and the other changed. Each scale appeared to be more sensitive to specific age or functional subgroups.
DISCUSSION: The two scales, when used in combination, may increase the sensitivity to detect clinically meaningful changes in motor function in patients with SMA types 2 and 3.