Sleep health · 2025
Past shift work, melatonin receptor gene polymorphisms, and hyperhomocysteinemia among retired workers: The Dongfeng-Tongji cohort study.
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Mo Tingting, Zhang Weidong, Wang Yufei, Gao Hui, Li Wending, Peng Rong, Wang Hao, Yuan Yu, Zhang Xiaomin, He Meian, Guo Huan, Wu Tangchun, Long Pinpin
Аннотация
OBJECTIVES: This study aims to investigate the associations between past shift work and hyperhomocysteinemia and further explore the modification effects of MTNR1A rs12506228 and MTNR1B rs10830963 (2 single-nucleotide polymorphisms in melatonin receptor genes) on this association.
METHODS: Based on the data of 14,043 retirees from the Dongfeng-Tongji cohort, multivariate logistic regression was used to analyze the association between past shift work duration and hyperhomocysteinemia, and gene-environment interaction analysis was performed.
RESULTS: Among 14,043 retirees from the Dongfeng-Tongji cohort, we found that retirees with longer durations of past shift work were significantly associated with higher odds of hyperhomocysteinemia (odds ratio and 95% confidence interval for per 5-year increase: 1.04 [1.02-1.06], P<.001). Furthermore, MTNR1B rs10830963 significantly exacerbated the effect of long-duration past shift work on hyperhomocysteinemia odds (P-trend<.001, P-interaction=.01), and MTNR1A rs12506228 had a joint effect with past shift work on hyperhomocysteinemia odds (P-trend<.001, P-interaction=.89).
CONCLUSIONS: The long-term hazard of shift work on hyperhomocysteinemia persisted from past to post retirement, and such association could be modified by MTNR1B rs10830963.
METHODS: Based on the data of 14,043 retirees from the Dongfeng-Tongji cohort, multivariate logistic regression was used to analyze the association between past shift work duration and hyperhomocysteinemia, and gene-environment interaction analysis was performed.
RESULTS: Among 14,043 retirees from the Dongfeng-Tongji cohort, we found that retirees with longer durations of past shift work were significantly associated with higher odds of hyperhomocysteinemia (odds ratio and 95% confidence interval for per 5-year increase: 1.04 [1.02-1.06], P<.001). Furthermore, MTNR1B rs10830963 significantly exacerbated the effect of long-duration past shift work on hyperhomocysteinemia odds (P-trend<.001, P-interaction=.01), and MTNR1A rs12506228 had a joint effect with past shift work on hyperhomocysteinemia odds (P-trend<.001, P-interaction=.89).
CONCLUSIONS: The long-term hazard of shift work on hyperhomocysteinemia persisted from past to post retirement, and such association could be modified by MTNR1B rs10830963.