Psychiatry research. Neuroimaging · 2025
Does hyperventilation alter the prefrontal hemodynamics of panic disorder during cognitive task? A functional near-infrared spectroscopy (fNIRS) based study.
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Jayasankar Pavithra, Nichenmetla Sonika, Sreeraj Vanteemar S, Kumar Vijay, Chhabra Harleen, Manjunatha Narayana, Venkatasubramanian Ganesan, Reddy Y C Janardhan
Аннотация
BACKGROUND: Cerebral hypofrontality has been implicated in the pathophysiology of panic disorder, (PD). This study examined the effect of symptom provocation on prefrontal cortex activity during a cognitive task in PD patients and healthy controls (HC) using functional near-infrared spectroscopy (fNIRS).
METHODS: We included 20 drug-naïve PD patients and 20 HC. Participants performed the N-back task before and after hyperventilation, while prefrontal activation was recorded using fNIRS. Two-way repeated-measures ANOVA was used to analyze changes in task performance and brain activation.
RESULTS: There was a significant group effect for two-back D', F(1, 32) = 4.93, p = 0.03, η² = 0.13, indicating that PD participants performed worse than HC. A significant time × group interaction was observed during the zero-back task in LBA8 and right prefrontal regions: RBA10, RBA8, and RBA46 (all p < 0.05), suggesting that the HC group showed greater activation changes after hyperventilation.
CONCLUSION: Our findings highlight working memory deficits and prefrontal hypofunction in PD. The absence of right prefrontal deactivation after hyperventilation in the PD group, compared to HC, suggests altered right-hemisphere involvement in PD pathophysiology.
METHODS: We included 20 drug-naïve PD patients and 20 HC. Participants performed the N-back task before and after hyperventilation, while prefrontal activation was recorded using fNIRS. Two-way repeated-measures ANOVA was used to analyze changes in task performance and brain activation.
RESULTS: There was a significant group effect for two-back D', F(1, 32) = 4.93, p = 0.03, η² = 0.13, indicating that PD participants performed worse than HC. A significant time × group interaction was observed during the zero-back task in LBA8 and right prefrontal regions: RBA10, RBA8, and RBA46 (all p < 0.05), suggesting that the HC group showed greater activation changes after hyperventilation.
CONCLUSION: Our findings highlight working memory deficits and prefrontal hypofunction in PD. The absence of right prefrontal deactivation after hyperventilation in the PD group, compared to HC, suggests altered right-hemisphere involvement in PD pathophysiology.